275 Result(s)
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Chapter
Immunological Methods for the Detection of Polycyclic Aromatic Hydrocarbon-DNA and Protein Adducts
Sensitive immunological methods are now available for the detection and quantitation of carcinogen-DNA and protein adducts. Both monoclonal and polyclonal antibodies have been developed against DNA modified by...
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Chapter
5-Fluoro-2′-Deoxyuridine: Role of Schedule in its Therapeutic Efficacy
The fluorinated pyrimidines 5-fluorouracil (FUra) and 5-fluoro-2′-deoxyuridine (FdUrd) are drugs that have been shown to have clinical activity against colorectal carcinoma and other malignancies. Attempts to ...
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Chapter
Comparing Porcine Models of Coronary Restenosis
The use of swine to study the vascular response to injury has gained wide acceptance over the past 10 yr. Our approach to the porcine model has been focused on the evaluation of novel therapeutic approaches to...
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Liposome-Mediated Delivery of Genes and Oligonucleotides for the Treatment of Brain Tumors
Brain tumors present a great therapeutic challenge due to their very poor prognosis (Mahaley et al, 1989). On the other hand, brain tumors have some features that make them particularly attractive for in vivo ...
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Prenatal and Perinatal Development of Intestinal Transport and Brush Border Hydrolases in Pigs
Although the neonatal intestine is able to process milk and absorb the components, problems of digestion are common. Because of the limited availability of human fetal and neonatal tissues, relatively little i...
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Chapter
Evaluation of the Reliability of cDNA Microarray Technique
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Chapter
Microfabricated Chip Electrophoresis Technology for DNA Analysis
In this report, two microfabricated chip electrophoresis techniques and several application studies were tested for rapid and high-resolution separation of double-stranded (ds)DNA. In one technique, low-viscos...
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Chapter
The Application of Novel Multi-Functional Microarray Slides for Immobilization Biomolecules
Microarray has revolutionized the study of molecular biology, especially the application in clinical diagnostics. When used in clinical diagnostics, microarray has to meet a high degree of reproducibility, rel...
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Chapter
An Integrated Biochemoinformatics System for Drug Discovery
Chipscreen Biosciences, Ltd. (www.chipscreen.com) is a drug discovery company specialized in novel small molecule therapeutics. Chipscreen has developed a proprietary chemical genomics approach to accelerate t...
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Protocol
NMR-Based Metabolomics for Biomarker Discovery
Metabolomics provides a powerful set of tools for pharmaceutical and clinical research in a number of important areas that include drug development, early disease detection, patient stratification for treatmen...
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Article
Überwachung von DNA-Schäden an Kontrollpunkten des Zellzyklus
In der vorgestellten Studie werden Arzneimittel-induzierte DNA-Schäden und deren Wirkung im Zellzyklus mittels Durchflusszytometrie bestimmt. Somit kann Durchflusszytometrie eine Hochdurchsatz-Plattform für da...
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Article
Open AccessClinical and animal research findings in pycnodysostosis and gene mutations of cathepsin K from 1996 to 2011
Cathepsin K (CTSK) is a member of the papain-like cysteine protease family. Mutations in the CTSK gene cause a rare autosomal recessive bone disorder called pycnodysostosis (OMIM 265800). In order to follow the a...
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Article
Open AccessESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure
Premature ovarian failure (POF) is a complex and heterogeneous disorder that is influenced by multiple genetic components. Numerous candidate gene studies designed to identify POF susceptibility loci have been...
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Article
Am Ende des Tunnels — Ribosomenassoziierte Proteinbiogenesefaktoren
Ribosome-bound protein biogenesis factors (RPBs) are essential for the early steps of protein biogenesis. A hallmark of RPBs is their ability to bind to the platform surrounding the exit of the ribosomal polyp...
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Protocol
Pharmacogenomics: Historical Perspective and Current Status
Pharmacogenomics and its predecessor pharmacogenetics study the contribution of genetic factors to the interindividual variability in drug efficacy and safety. One of the major goals of pharmacogenomics is to ...
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Article
Open AccessCompounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines
Many genetic diseases are due to defects in protein trafficking where the mutant protein is recognized by the quality control systems, retained in the endoplasmic reticulum (ER), and degraded by the proteasome...
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Article
Open AccessIdentification of a distinct mutation spectrum in the SMPD1 gene of Chinese patients with acid sphingomyelinase-deficient Niemann-Pick disease
Clinical observations and molecular analysis of the SMPD1 gene in Chinese patients with acid sphingomyelinase deficiency Niemann-Pick disease (NPD) are scarce.
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Article
Open AccessAdult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by a non-neutral HDAC6 variant
We studied a family including two half-siblings, sharing the same mother, affected by slowly progressive, adult-onset neurological syndromes. In spite of the diversity of the clinical features, characterized b...
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Article
Open AccessOlmsted syndrome: exploration of the immunological phenotype
Olmsted syndrome is a rare congenital skin disorder presenting with periorifical hyperkeratotic lesions and mutilating palmoplantar keratoderma, which is often associated with infections of the keratotic area....
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Article
Open AccessThe molecular mechanisms on glomangiopericytoma invasion
To observed the imaging and pathological features of the glomangiopericytoma.
