Abstract
The use of swine to study the vascular response to injury has gained wide acceptance over the past 10 yr. Our approach to the porcine model has been focused on the evaluation of novel therapeutic approaches to the treatment of arterial restenosis. It is from this perspective that the following discussion was prepared. Thus, the purpose of this brief review is to present a rationale for the use of the pig, describe the general technique, compare and contrast some of the variations in the use of the model and highlight relevant similarities to the human problem of coronary restenosis.
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References
Lee, K.T., 1986, Swine as animal models in cardiovascular research, in: Swine in Biomedical Research Volume 3 (M.E. Tumbleson, ed.), Plenum Press, New York, pp. 1481–1496.
Hughes, H.C., 1986, Swine in cardiovascular research, Lab. Anim. Sci. 36:348–350.
Horneffer, P.J., Gott, V.L., and Gardner, T.J., 1986, Swine as a cardiac surgical model, in: Swine in Biomedical Research Volume 1 (M.E. Tumbleson, ed.), Plenum Press, New York, pp. 321–325.
Smith, G.S., Smith, J.L., and Mameesh, M.S., 1964, Hypertension and cardiovascular abnormalities in starved-refed swine, J. Nutr. 82:172–182.
Mahley, R.W., and Weisgraber, K.H., 1974, An electrophoretic method for the quantitative isolation of human and swine plasma lipoproteins, Biochemistry 13:1964–1969.
Folts, J.D., and Rowe, G.G., 1983, Acute thrombus formation in stenosed pig coronary arteries, causing sudden death by ventricular fibrillation, Circulation 68(Suppl III):264.
Leach, C.M., and Thorburn, G.D., 1982, A comparative study of collagen-induced thromboxane release from platelets of different species: Implications for human atherosclerosis models, Prostaglandins 24:47–59.
Jokinen, M.R., Clarkson, T.B., and Prichard, P.W., 1985, Recent advances in molecular pathology: animals models in atherosclerosis research, Exp. Molec. Pathol. 42:1–28.
Getty, R., 1965, Gross and microscopic occurrence and distribution of spontaneous atherosclerosis in the arteries of swine, in: Comparative Atherosclerosis (A. Robert, and E. Straus, eds.), Harper and Row, New York, pp. 11–20.
Zugibe, F.T., 1965, Atherosclerosis in the miniature pig, in: Comparative Atherosclerosis (A. Robert, and E. Straus, eds.), Harper and Row, New York, pp. 37–42.
Rodgers, G.P., Minor, S.T., and Robinson, K., 1990, Adjuvant therapy for intracoronary stents: investigations in atherosclerotic swine, Circulation 82:560–569.
Schwartz, R.S., Murphy, J.G., and Edwards, W.D., 1990, Restenosis after balloon angioplasty: a practical proliferative model in porcine coronary arteries, Circulation 82:2190–2200.
Virmani, R., Farb, A., and Burke, A.P., 1994, Coronary angioplasty from the perspective of atherosclerotic plaque: morphologic predictors of immediate success and restenosis, Am. Heart J. 127:163–179.
Schwartz, R.S., Huber, K.C., Murphy, J.G., Edwards, W.D., Camrud, A.R., Vlietstra, R.E., and Holmes, D.R., 1992, Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model, J. Am. Coll. Cardiol. 19:267–274.
Karas, S.P., Gravanis, M.B., Santoian, E.C., Robinson, K.A., Anderberg, K.A., and King, S.B., 1992, Coronary intimal proliferation after balloon injury and stenting in swine: an animal model of restenosis, J. Am. Coll. Cardiol. 20:467–474.
Steele, P.M., Chesebro, J.H., and Stanson, A.W., 1985, Balloon angioplasty: natural history of the pathophysiological response to injury in a pig model, Circ. Res. 57:105–112.
Humphrey, W.R., Simmons, C.A., Toombs, C.F., and Shebuski, R.J., 1994, Induction of neointimal hyperlasia by coronary angioplasty balloon overinflation: comparison of feeder pigs to Yucatan minipigs, Am. Heart J. 127:20–31.
Buchwald, A.B., Unterberg, C., Nebendahl, K., Grone, H.J., and Wiegand, V., 1992, Low-molecular-weight heparin reduces neointimal proliferation after coronary stent implantation in hypercholesterolemic minipigs, Circulation 86:531–537.
Grinstead, W.C., Rodger, G.P., Mazure, W., French, B.A., Cromeens, D., Van Pelt, C., West, S.M., and Raizner, A.E., 1994, Comparison of three porcine restenosis models: the relative importance of hypercholesterolemia, endothelial abrasion, and stenting, Coronary Artery Dis. 5:425–434.
Schwartz, R.S., Edwards, W.D., Bailey, K.R., Camrud, A.R., Jorgenson, M.A., and Holmes, D.R., Jr., 1994, Differential neointimal response to coronary artery injury in pigs and dogs: implications for restenosis models, Arterioscler. Thromb. 14:395–400.
Schwartz, S.M., deBois, D., and Obrien, E.R.M., 1995, The intima, Circ. Res. 77:445–465.
White, C.J., Ramee, S.R., Banks, A.K., Mesa, J.E., Chokshi, S., and Isner, J.M., 1992, Anew balloon-expandable tantlum coil stent: angiographic patency and histologic findings in an atherogenic swine model, J. Am. Coll. Cardiol. 19:870–876.
Carter, A.J., Laird, J.R., Farb, A., Kufs, W., Wortham, D.C., and Virmani, R., 1994, Morphologic characteristics of lesion formation and time course of smooth muscle cell proliferation in a porcine proliferative restenosis model, J. Am. Coll. Cardiol. 24:1398–1405.
Schwartz, R.S., and Holmes, D.R., 1994, Pigs, dogs, baboons and man: lessons for stenting from animal studies, J. Interven. Cardiol. 7:355–368.
Schwartz, R.S., Edwards, W.D., Huber, K.C., Antoniades, L.C., Bailey, K.R., Camrud, A.R., Jorgenson, M.A., and Holmes, D.R., 1993, Coronary restenosis: prospects for solution and new perspectives from a porcine model, Mayo Clin. Proc. 68:54–62.
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© 1996 Springer Science+Business Media New York
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Willette, R.N., Zhang, H., Louden, C., Jackson, R.K. (1996). Comparing Porcine Models of Coronary Restenosis. In: Tumbleson, M.E., Schook, L.B. (eds) Advances in Swine in Biomedical Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5885-9_14
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DOI: https://doi.org/10.1007/978-1-4615-5885-9_14
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