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Article
Open AccessZOom Delivered Intervention Against Cognitive decline (ZODIAC) COVID-19 pandemic adaptations to the Post-Ischaemic Stroke Cardiovascular Exercise Study (PISCES): protocol for a randomised controlled trial of remotely delivered fitness training for brain health
Stroke increases subsequent dementia risk yet there are no specific post-stroke therapies to protect cognition. Cardiorespiratory exercise is recommended for secondary prevention of stroke and may be neuroprot...
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Article
Open AccessProtocol for a prospective study evaluating circulating tumour cells status to predict radical prostatectomy treatment failure in localised prostate cancer patients (C-ProMeta-1)
Treatment decisions in prostate cancer (PCa) rely on disease stratification between localised and metastatic stages, but current imaging staging technologies are not sensitive to micro-metastatic disease. Circ...
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Article
Open AccessA live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity
The four dengue virus serotypes co-circulate globally and cause significant human disease. Dengue vaccine development is challenging because some virus-specific antibodies are protective, while others are impl...
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Article
Open AccessPANTHER: AZD8931, inhibitor of EGFR, ERBB2 and ERBB3 signalling, combined with FOLFIRI: a Phase I/II study to determine the importance of schedule and activity in colorectal cancer
Epidermal growth factor receptor (EGFR) is a therapeutic target to which HER2/HER3 activation may contribute resistance. This Phase I/II study examined the toxicity and efficacy of high-dose pulsed AZD8931, an...
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Article
Open AccessFactors Affecting Domiciliary Non-Invasive Ventilation Compliance
Few international studies have investigated factors affecting domiciliary non-invasive ventilation (D-NIV) compliance, and data from the UK are limited. We assessed compliance (defined as ≥ 4 h/night for at le...
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Chapter
Doubly Nonlocal Cahn–Hilliard Equations
This chapter focuses on a doubly nonlocal Cahn–Hilliard system that involves weakly singular kernels in the operators and which allows discontinuous solutions. The system is studied first in a linearized setti...
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Article
Open AccessDengue virus-like particles mimic the antigenic properties of the infectious dengue virus envelope
The 4 dengue serotypes (DENV) are mosquito-borne pathogens that are associated with severe hemorrhagic disease. DENV particles have a lipid bilayer envelope that anchors two membrane glycoproteins prM and E. T...
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Article
Open AccessCharacterization of HIV-1 envelopes in acutely and chronically infected injection drug users
Mucosally acquired human immunodeficiency virus type 1 (HIV-1) infection results from a limited number of variants, and these infecting strains potentially have unique properties, such as increased susceptibil...
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Chapter and Conference Paper
Interoperable Systems and Software Evolution: Issues and Approaches
Interoperability is essential for modern enterprise software; one of the most promising ways of providing interoperability is though Services Oriented Architectures (SOA) usually implemented using the Web Serv...
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Article
Bilateral Common Carotid Artery Ligation Transiently Changes Brain Lipid Metabolism in Rats
Brain lipid metabolism was studied in rats following permanent bilateral common carotid artery ligation (BCCL), a model for chronic cerebral hypoperfusion. Unesterified (free) fatty acids (uFA) and acyl-CoA co...
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Article
Medical Student Surgery Elective in Rural Haiti: A Novel Approach to Satisfying Clerkship Requirements While Providing Surgical Care to an Underserved Population
The addition of global health programs to medical school training results in graduates with enhanced clinical skills and increased sensitivity to cost issues. Funding from U.S. medical schools has been unable ...
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Article
Überwachung von DNA-Schäden an Kontrollpunkten des Zellzyklus
In der vorgestellten Studie werden Arzneimittel-induzierte DNA-Schäden und deren Wirkung im Zellzyklus mittels Durchflusszytometrie bestimmt. Somit kann Durchflusszytometrie eine Hochdurchsatz-Plattform für da...
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Article
The Role of Psychosomatic Medicine in Global Health Care
This article reviews the principles and skills involved with psychosomatic medicine and their potential ability to improve global health care. New awareness of the escalating global public health impact of non...
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Article
Open AccessUsing Abbreviated Injury Scale (AIS) codes to classify Computed Tomography (CT) features in the Marshall System
The purpose of Abbreviated Injury Scale (AIS) is to code various types of Traumatic Brain Injuries (TBI) based on their anatomical location and severity. The Marshall CT Classification is used to identify thos...
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Article
Imaging apomorphine stimulation of brain arachidonic acid signaling via D2-like receptors in unanesthetized rats
Because of the important role of dopamine in neurotransmission, it would be useful to be able to image brain dopamine receptor-mediated signal transduction in animals and humans. Administering the D1–D2 receptor ...
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Article
Clinical considerations in breast cancer sentinel lymph node map**: A moffitt review
Lymphatic map** redefined the clinical significance of axillary lymph nodes in the treatment of breast cancer. Current literature supports the concept that any patient diagnosed with invasive breast cancer s...
