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Article
Open AccessNovel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat
Glucagon-like peptide-1 (GLP-1) and its mimetics reduce infarct size in the setting of acute myocardial ischemia/reperfusion (I/R) injury. However, the short serum half-life of GLP-1 and its mimetics may limit...
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Article
Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells
Lysophosphatidylcholine (LPC) is the major bioactive lipid component of oxidized LDL, thought to be responsible for many of the inflammatory effects of oxidized LDL described in both inflammatory and endotheli...
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Protocol
Quantitative Analysis of Orphan G Protein-Coupled Receptor mRNAs by TaqMan® Real-Time PCR
Historically, the G protein-coupled receptor (GPCR) protein family has proven to be an extremely tractable target class (1). It is estimated that approximately one-half of all drugs currently marketed exert their...
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Article
Urotensin-II: a novel systemic hypertensive factor in the cat
Urotensin-II, a potent mammalian vasoconstrictor, may play a role in the etiology of essential hypertension. However, a species suitable for assessing such a role, one where a “classical” systemic hypertensive...
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Chapter
p38 MAPK in cardiac remodeling and failure: cytokine signaling and beyond
Compelling evidence suggests that a complex interplay between various mitogenactivated protein kinases (MAPK) mediate adaptive and maladaptive changes in the myocardium. MAPKs are serine-threonine protein kina...
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Article
Erratum: Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
Nature 401, 282–286; 1999 Units for the x-axis of Fig. 5b–g should be pmol kg -1 (and not nmol kg-1 as published). In Fig. 5f, the right numeral should be 1,000.
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Article
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
Urotensin-II (U-II) is a vasoactive ‘somatostatin-like’ cyclic peptide which was originally isolated from fish spinal cords1,2, and which has recently been cloned from man3. Here we describe the identification of...
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Chapter
Comparing Porcine Models of Coronary Restenosis
The use of swine to study the vascular response to injury has gained wide acceptance over the past 10 yr. Our approach to the porcine model has been focused on the evaluation of novel therapeutic approaches to...
