-
Article
Near-infrared-II fluorescence/magnetic resonance double modal imaging of transplanted stem cells using lanthanide co-doped gadolinium oxide nanoparticles
To ensure maximum therapeutic safety and efficacy of stem cell transplantation, it is essential to observe the kinetics of behavior, accumulation, and engraftment of transplanted stem cells in vivo. However, ...
-
Article
Open AccessSpatial exosome analysis using cellulose nanofiber sheets reveals the location heterogeneity of extracellular vesicles
Extracellular vesicles (EVs), including exosomes, are recognized as promising functional targets involved in disease mechanisms. However, the intravital heterogeneity of EVs remains unclear, and the general li...
-
Article
Open AccessMicro- and nanochamber array system for single enzyme assays
Arrays of small reaction containers, ranging from 624 femtoliters (10–15 L) to 270 attoliters (10–18 L), for capturing a single enzyme molecule and measuring the activity were developed along with a new reversibl...
-
Article
Open AccessHigh-performance glass filters for capturing and culturing circulating tumor cells and cancer-associated fibroblasts
Various liquid biopsy methods have been developed for the non-invasive and early detection of diseases. In particular, the detection of circulating tumor cells (CTCs) and cancer-associated fibroblasts (CAFs) i...
-
Reference Work Entry In depth
Nanobiodevice for Nucleic Acid Sensing
Nanobiodevices, a technology characterized by engineered nanostructures, have attracted extensive interest as a new generation bioanalytical tool that allows accessing the information contained in nucleic acid...
-
Article
Fluorescent/magnetic nano-aggregation via electrostatic force between modified quantum dot and iron oxide nanoparticles for bimodal imaging of U87MG tumor cells
Imaging technology based on novel nanomaterials is burgeoning as a potential tool for exploring various physiological processes. We herein report a fluorescent and magnetic nanoprobe (QMNP-RGD) for bimodal ima...
-
Living Reference Work Entry In depth
Nanobiodevice for Nucleic Acid Sensing
Nanobiodevices, a technology characterized by engineered nanostructures, have attracted extensive interest as a new generation bioanalytical tool that allows accessing the information contained in nucleic acid...
-
Article
Oxide Nanowire Microfluidic Devices for Capturing Single-stranded DNAs
Since DNA analysis is the fundamental process for most applications in biomedical fields, capturing DNAs with high efficiency is important. Here, we used several oxide nanowire microfluidic devices to capture ...
-
Article
Open AccessCo-continuous structural effect of size-controlled macro-porous glass membrane on extracellular vesicle collection for the analysis of miRNA
Recent studies have shown that extracellular vesicles (EVs) can be utilized as appropriate and highly specific biomarkers in liquid biopsy for the diagnosis and prognosis of serious illness. However, there are...
-
Article
Open AccessWide-field fluorescent nanodiamond spin measurements toward real-time large-area intracellular thermometry
Measuring optically detected magnetic resonance (ODMR) of diamond nitrogen vacancy centers significantly depends on the photon detectors used. We study camera-based wide-field ODMR measurements to examine the ...
-
Article
Photolithographically Constructed Single ZnO Nanowire Device and Its Ultraviolet Photoresponse
A sparse ZnO nanowire array with aspect ratio of ca. 120 and growth rate of 1 μm/h was synthesized by controlling the density of seeds at the initial stage of nanowire growth. The spatially-separated nanowires...
-
Article
Open AccessFace-selective tungstate ions drive zinc oxide nanowire growth direction and dopant incorporation
Tailoring the elemental do** of inorganic nanowires remains an important challenge due to complex dopant incorporation pathways. Here we report that the face-selectivity of tungstate ions controls growth dir...
-
Article
A Method to Analyze Urinary Extracellular Vesicles
Extracellular vesicles (EVs) play an important role in cell-to-cell communication by carrying molecular messages that reflect physiological and pathological conditions of the parent cells. EVs have been identi...
-
Article
Open AccessSubstantial Narrowing on the Width of “Concentration Window” of Hydrothermal ZnO Nanowires via Ammonia Addition
A crystal growth of hydrothermal ZnO nanowires essentially requires a concentration control within so-called “concentration window”, where the anisotropic crystal growth of ZnO nanowires preferentially occurs....
-
Chapter
Nanobiodevices for Cancer Diagnostics and Stem Cell Therapeutics
This chapter describes the potential of multifunctional nanobiodevices in combination with quantum dots (QDs) to meet the requirements of diagnostic and theranostic systems. Nanobiodevices are primed to be pow...
-
Article
PM2.5 Particle Detection in a Microfluidic Device by Using Ionic Current Sensing
We have demonstrated a PM2.5 analysis method that adds information on the number concentration and size by using microfluidic-based ionic current sensing with a bridge circuit. The bridge circuit allows for suppr...
-
Article
In Vivo Imaging Technology of Transplanted Stem Cells Using Quantum Dots for Regenerative Medicine
Quantum dots (QDs) have excellent fluorescence properties in comparison to traditional fluorescence probes. Thus, the optical application of QDs is rapidly expanding to each field of analytical chemistry. In t...
-
Article
Open AccessImaging of angiogenesis of human umbilical vein endothelial cells by uptake of exosomes secreted from hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC) is a typical hyper-vascular tumor, so the understanding the mechanisms of angiogenesis in HCC is very important for its treatment. However, the influence of the exosomes secreted...
-
Article
Open AccessDiscriminating single-bacterial shape using low-aspect-ratio pores
Conventional concepts of resistive pulse analysis is to discriminate particles in liquid by the difference in their size through comparing the amount of ionic current blockage. In sharp contrast, we herein rep...
-
Article
Open AccessTransplantation of bioengineered rat lungs recellularized with endothelial and adipose-derived stromal cells
Bioengineered lungs consisting of a decellularized lung scaffold that is repopulated with a patient’s own cells could provide desperately needed donor organs in the future. This approach has been tested in rat...
