18 Result(s)
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Article
Open AccessAssessment of associations between neutrophil extracellular trap biomarkers in blood and thrombi in acute ischemic stroke patients
Inflammation including immunothrombosis by neutrophil extracellular traps (NETs) has important implications in acute ischemic stroke and can affect reperfusion status, susceptibility to stroke associated infec...
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Article
Open AccessButyrylcholinesterase activity in patients with postoperative delirium after cardiothoracic surgery or percutaneous valve replacement- an observational interdisciplinary cohort study
Postoperative delirium is a frequent and severe complication after cardiac surgery. Activity of butyrylcholinesterase (BChE) has been discussed controversially regarding a possible role in its development. Thi...
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Open AccessLarge diameter hemicraniectomy does not improve long-term outcome in malignant infarction
In malignant cerebral infarction decompressive hemicraniectomy has demonstrated beneficial effects, but the optimum size of hemicraniectomy is still a matter of debate. Some surgeons prefer a large-sized hemic...
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Article
Open AccessReduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation
Calcineurin inhibitors (CNI) can cause long-term impairment of brain function. Possible pathomechanisms include alterations of the cerebral immune system. This study used positron emission tomography (PET) ima...
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Determination of Turkish norms of psychometric tests for diagnosing minimal hepatic encephalopathy and proposal of a high sensitive screening test battery
Psychometric hepatic encephalopathy score (PHES) needs local standardization.
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Open AccessMultiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury
Circulating autoantibodies (AB) of different immunoglobulin classes (IgM, IgA, and IgG), directed against the obligatory N-methyl-d-aspartate-receptor subunit NR1 (NMDAR1-AB), belong to the mammalian autoimmune r...
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PET and SPECT in Hepatic and Uraemic Encephalopathy
Liver or kidney failure can disturb brain function to a variable extent. If organ failure is treated successfully, brain function is normally, at least in part, restored. A broad spectrum of radiotracer imagin...
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Open AccessReliable quantification of 18F-GE-180 PET neuroinflammation studies using an individually scaled population-based input function or late tissue-to-blood ratio
Tracer kinetic modeling of tissue time activity curves and the individual input function based on arterial blood sampling and metabolite correction is the gold standard for quantitative characterization of mic...
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Open AccessSeptal total atrial conduction time for prediction of atrial fibrillation in embolic stroke of unknown source: a pilot study
Subclinical atrial fibrillation (AF) is the underlying cause in a relevant part of patients with embolic stroke of unknown source (ESUS). This pilot study aims to identify novel echocardiographic parameters pr...
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Article
ADAMTS13 activity is associated with early neurological improvement in acute ischemic stroke patients treated with intravenous thrombolysis
Although intravenous thrombolysis (IVT) with recombinant tissue-plasminogen-activator represents a highly effective treatment in acute ischemic stroke patients, not every patient benefits. We hypothesized that...
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Article
Open AccessHepatic Encephalopathy: Definition, Clinical Grading and Diagnostic Principles
In general, hepatic encephalopathy (HE) is defined as a brain dysfunction caused by liver insufficiency and/or portal-systemic blood shunting. This article relates to the so-called type C HE: that is, HE in pa...
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Open AccessEpilepsy as a risk factor for hepatic encephalopathy in patients with cirrhosis: a cohort study
Epilepsy is associated with an increased mortality among cirrhosis patients, but the reasons are unknown. We aimed to determine whether epilepsy is a risk factor for develo** hepatic encephalopathy (HE), whi...
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Chapter
PET and SPECT in Hepatic and Uraemic Encephalopathy
Liver or kidney failure can disturb brain function to a variable extent. If organ failure is treated successfully, brain function is normally at least in part restored. A broad spectrum of radiotracer imaging ...
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Article
Quantitative MRI shows cerebral microstructural damage in hemolytic–uremic syndrome patients with severe neurological symptoms but no changes in conventional MRI
Severe neurological symptoms in Shiga toxin-producing Escherichia coli infection associated hemolytic–uremic syndrome (STEC–HUS) are often accompanied by none or only mild alterations of cerebral magnetic resonan...
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Article
Hepatic encephalopathy after treatment with temozolomide
Temozolomide in combination with radiation has been in use for more than 5 years for the therapy of glioblastoma. Known adverse effects concerning the gastrointestinal system are elevation of liver enzymes. We...
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Article
Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation
The aim of our study was to evaluate the safety and efficacy of intra-arterial (IA) thrombolysis using recombinant tissue plasminogen activator (rt-PA) in patients with acute stroke due to occlusion in the ant...
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Article
Correlative assessment of cerebral blood flow obtained with perfusion CT and positron emission tomography in symptomatic stenotic carotid disease
Twelve patients with ICA stenosis underwent dynamic perfusion computed tomography (CT) and positron emission tomography (PET) studies at rest and after acetazolamide challenge. Cerebral blood flow (CBF) maps o...
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Chapter
Hepatic Coma
Hepatic encephalopathy (HE) arises as a complication in fulminant hepatic failure (FHF) as well as in chronic liver failure. Initially it is characterized by minor mental and personality changes and discrete c...
