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Open AccessAssessment of associations between neutrophil extracellular trap biomarkers in blood and thrombi in acute ischemic stroke patients
Inflammation including immunothrombosis by neutrophil extracellular traps (NETs) has important implications in acute ischemic stroke and can affect reperfusion status, susceptibility to stroke associated infec...
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Article
Open AccessButyrylcholinesterase activity in patients with postoperative delirium after cardiothoracic surgery or percutaneous valve replacement- an observational interdisciplinary cohort study
Postoperative delirium is a frequent and severe complication after cardiac surgery. Activity of butyrylcholinesterase (BChE) has been discussed controversially regarding a possible role in its development. Thi...
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Article
Open AccessInterplay between driveline infection, vessel wall inflammation, cerebrovascular events and mortality in patients with left ventricular assist device
In patients with left ventricular assist device (LVAD), infections and thrombotic events represent severe complications. We investigated device-specific local and systemic inflammation and its impact on cerebr...
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Article
Open AccessLarge diameter hemicraniectomy does not improve long-term outcome in malignant infarction
In malignant cerebral infarction decompressive hemicraniectomy has demonstrated beneficial effects, but the optimum size of hemicraniectomy is still a matter of debate. Some surgeons prefer a large-sized hemic...
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Article
Open AccessCorrection: Association of dimethylarginines and mediators of inflammation after acute ischemic stroke
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Open AccessReduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation
Calcineurin inhibitors (CNI) can cause long-term impairment of brain function. Possible pathomechanisms include alterations of the cerebral immune system. This study used positron emission tomography (PET) ima...
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Article
Determination of Turkish norms of psychometric tests for diagnosing minimal hepatic encephalopathy and proposal of a high sensitive screening test battery
Psychometric hepatic encephalopathy score (PHES) needs local standardization.
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Article
Open AccessAddressing the ‘hypoxia paradox’ in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues
Since fall 2019, SARS-CoV-2 spread world-wide, causing a major pandemic with estimated ~ 220 million subjects affected as of September 2021. Severe COVID-19 is associated with multiple organ failure, particula...
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Article
Open AccessMultiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury
Circulating autoantibodies (AB) of different immunoglobulin classes (IgM, IgA, and IgG), directed against the obligatory N-methyl-d-aspartate-receptor subunit NR1 (NMDAR1-AB), belong to the mammalian autoimmune r...
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PET and SPECT in Hepatic and Uraemic Encephalopathy
Liver or kidney failure can disturb brain function to a variable extent. If organ failure is treated successfully, brain function is normally, at least in part, restored. A broad spectrum of radiotracer imagin...
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Article
Open AccessDistinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis
Inflammatory processes are crucial in atherosclerosis and atherothrombosis. This study aimed to identify a cytokine-pattern that is associated with plaque-vulnerability or symptomatic state in comprehensively ...
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Article
Open AccessReliable quantification of 18F-GE-180 PET neuroinflammation studies using an individually scaled population-based input function or late tissue-to-blood ratio
Tracer kinetic modeling of tissue time activity curves and the individual input function based on arterial blood sampling and metabolite correction is the gold standard for quantitative characterization of mic...
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Article
Open AccessErythropoietin as candidate for supportive treatment of severe COVID-19
In light of the present therapeutic situation in COVID-19, any measure to improve course and outcome of seriously affected individuals is of utmost importance. We recap here evidence that supports the use of h...
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Article
Open AccessSeptal total atrial conduction time for prediction of atrial fibrillation in embolic stroke of unknown source: a pilot study
Subclinical atrial fibrillation (AF) is the underlying cause in a relevant part of patients with embolic stroke of unknown source (ESUS). This pilot study aims to identify novel echocardiographic parameters pr...
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Article
ADAMTS13 activity is associated with early neurological improvement in acute ischemic stroke patients treated with intravenous thrombolysis
Although intravenous thrombolysis (IVT) with recombinant tissue-plasminogen-activator represents a highly effective treatment in acute ischemic stroke patients, not every patient benefits. We hypothesized that...
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Metabolische Enzephalopathien
Metabolische Enzephalopathien stellen oft eine diagnostische Herausforderung dar, da sie sich klinisch sehr variabel präsentieren, und – außer im Falle einer schweren Hypo- oder Hyperglykämie – regelhaft ander...
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Article
Open AccessMarkers of endothelial pathology to support detection of atrial fibrillation in embolic stroke of undetermined source
A relevant part of embolic strokes of undetermined source (ESUS) is assumed to be cardiogenic. As shown previously, certain biomarkers of endothelial pathology are related to atrial fibrillation (AF). In this ...
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Article
Cerebral patterns of neuropsychological disturbances in hepatitis C patients
Neuropsychiatric symptoms and cognitive impairment have been consistently reported in patients with hepatitis C virus (HCV) infection. Since the mechanisms behind remain to be established, the present study at...
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Article
Open AccessHepatic Encephalopathy: Definition, Clinical Grading and Diagnostic Principles
In general, hepatic encephalopathy (HE) is defined as a brain dysfunction caused by liver insufficiency and/or portal-systemic blood shunting. This article relates to the so-called type C HE: that is, HE in pa...
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Article
Open AccessDimethylarginines in patients with intracerebral hemorrhage: association with outcome, hematoma enlargement, and edema
Asymmetric dimethylarginine (ADMA)––the most potent endogenous NO-synthase inhibitor, has been regarded as mediator of endothelial dysfunction and oxidative stress. Considering experimental data, levels of ADM...
