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Article
Aging promotes metabolic dysfunction-associated steatotic liver disease by inducing ferroptotic stress
Susceptibility to the biological consequences of aging varies among organs and individuals. We analyzed hepatocyte transcriptomes of healthy young and aged male mice to generate an aging hepatocyte gene signat...
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Article
Envisioning how to advance the MASH field
Since 1980, the cumulative effort of scientists and health-care stakeholders has advanced the prerequisites to address metabolic dysfunction-associated steatotic liver disease (MASLD), a prevalent chronic non-...
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Article
Open AccessA humanized mouse model for adeno-associated viral gene therapy
Clinical translation of AAV-mediated gene therapy requires preclinical development across different experimental models, often confounded by variable transduction efficiency. Here, we describe a human liver ch...
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Article
Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing
Cellular senescence is a stress-induced, stable cell cycle arrest phenotype which generates a pro-inflammatory microenvironment, leading to chronic inflammation and age-associated diseases. Determining the fun...
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Article
Open AccessDeep learning-based quantification of NAFLD/NASH progression in human liver biopsies
Non-alcoholic fatty liver disease (NAFLD) affects about 24% of the world's population. Progression of early stages of NAFLD can lead to the more advanced form non-alcoholic steatohepatitis (NASH), and ultimate...
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Article
Open AccessSpermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression
Spermidine is a natural polyamine that has health benefits and extends life span in several species. Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key enzymes that utilize spermidine t...
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Article
Why we need to curb the emerging worldwide epidemic of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease worldwide, mainly because of the massive parallel global increase in obesity. Extensive public-health and political effo...
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Article
Microbial nitrogen limitation in the mammalian large intestine
Resource limitation is a fundamental factor governing the composition and function of ecological communities. However, the role of resource supply in structuring the intestinal microbiome has not been establis...
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Chapter and Conference Paper
Developmental Morphogens & Recovery from Alcoholic Liver Disease
Alcohol-induced steatohepatitis (ASH) increases the risk for both clinically-severe acute alcoholic hepatitis and eventual cirrhosis. The mechanisms that control ASH pathogenesis and progression are unclear bu...
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Article
Open AccessThymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling
The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that TB4 influences HSC activation through hedgehog (Hh)...
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Article
Open AccessLoss of pericyte smoothened activity in mice with genetic deficiency of leptin
Obesity is associated with multiple diseases, but it is unclear how obesity promotes progressive tissue damage. Recovery from injury requires repair, an energy-expensive process that is coupled to energy avail...
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Article
Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model
Nonalcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease and second indication for liver transplantation in the Western world. Effective therapy is still not available. Previou...
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Chapter
Animal Models of Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world, accompanying the rise in obesity and its related metabolic disorders. Though research in the field is vibrant, en...
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Article
Open AccessStatins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension
Liver cirrhosis but also portal vein obstruction cause portal hypertension (PHT) and angiogenesis. This study investigated the differences of angiogenesis in cirrhotic and non-cirrhotic PHT with special emphas...
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Article
Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma
Initiation and progression of hepatocellular carcinoma (HCC) is intimately associated with a chronically diseased liver tissue. This diseased liver tissue background is a drastically different microenvironment...
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Article
Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse
Recent studies have reported that NF-κB mediated down-regulation of miRNA-29 and lower expression of miRNA-29 promoted the deposition of collagens in fibrotic liver. Our previous research demonstrated that the...
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Article
MicroRNA Expression Differentiates Squamous Epithelium from Barrett’s Esophagus and Esophageal Cancer
Current strategies fail to identify most patients with esophageal adenocarcinoma (EAC) before the disease becomes advanced and incurable. Given the dismal prognosis associated with EAC, improvements in detecti...
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Article
NAFLD, NASH and liver cancer
The incidence of NAFLD, which increases the risk of liver cancer, is increasing to epidemic proportions. This Review outlines the correlations between liver cancer and NAFLD-related cirrhosis, and the role of ...
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Article
Open AccessDifferential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines
Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellula...
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Article
Neighborhood watch orchestrates liver regeneration
Liver injury promotes the outgrowth of cell types that are relatively rare in healthy livers, including progenitors and stromal cells. A new study shows that the type of injury influences the cellular composit...
