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Article
Chirurgische Therapieindividualisierung bei Sarkomen der Extremitäten
Sarkome der Extremitäten sind seltene Entitäten, deren Therapie einer besonderen Expertise bedarf. Auch wenn die Behandlung der Patienten stets interdisziplinär erfolgt, ist die chirurgische R0-Resektion der G...
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Article
Chirurgische Therapieindividualisierung bei Sarkomen der Extremitäten
Sarkome der Extremitäten sind seltene Entitäten, deren Therapie einer besonderen Expertise bedarf. Auch wenn die Behandlung der Patienten stets interdisziplinär erfolgt, ist die chirurgische R0-Resektion der G...
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Article
Open AccessImpaired FADD/BID signaling mediates cross-resistance to immunotherapy in Multiple Myeloma
The treatment landscape in multiple myeloma (MM) is shifting from genotoxic drugs to immunotherapies. Monoclonal antibodies, immunoconjugates, T-cell engaging antibodies and CART cells have been incorporated i...
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Article
Open AccessClinical characterisation of women with persistent genital arousal disorder: the iPGAD-study
Persistent Genital Arousal Disorder (PGAD) is a rare condition—mostly in women—where patients perceive prolonged genital arousal without any sexual desire or stimulation. Etiopathological considerations reach ...
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Article
Open AccessAnalysis of deep grey nuclei susceptibility in early childhood: a quantitative susceptibility map** and R2* study at 3 Tesla
Aging is the most significant determinant for brain iron accumulation in the deep grey matter. Data on brain iron evolution during brain maturation in early childhood are limited. The purpose of this study was...
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Article
Open AccessSPG7 mutations in amyotrophic lateral sclerosis: a genetic link to hereditary spastic paraplegia
Amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP) are motor neuron diseases sharing clinical, pathological, and genetic similarities. While biallelic SPG7 mutations are known to cause re...
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Living Reference Work Entry In depth
Kindlicher Knick-Senk-Fuß
Der kindliche Knick-Senk-Fuß stellt eine häufige Entität bei Kleinkindern dar. Ein asymptomatischer, entwicklungsbedingter, flexibler kindlicher Knick-Senk-Fuß, insbesondere bei Kindern unter 6 Jahren ohne neu...
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Article
Cerebral patterns of neuropsychological disturbances in hepatitis C patients
Neuropsychiatric symptoms and cognitive impairment have been consistently reported in patients with hepatitis C virus (HCV) infection. Since the mechanisms behind remain to be established, the present study at...
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Chapter
Multiple Sklerose und andere autoimmune ZNS-Erkrankungen
Autoimmunerkrankungen des zentralen Nervensystems (ZNS) stellen eines der sich am schnellsten entwickelnden Gebiete in der Neurologie dar. Die Entdeckung neuer Autoantikörper hat zur Beschreibung neuer Krankhe...
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Article
Open AccessDimethylarginines in patients with intracerebral hemorrhage: association with outcome, hematoma enlargement, and edema
Asymmetric dimethylarginine (ADMA)––the most potent endogenous NO-synthase inhibitor, has been regarded as mediator of endothelial dysfunction and oxidative stress. Considering experimental data, levels of ADM...
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Article
Contribution of QSM Imaging to the Diagnosis of the Rare Syndrome of Leukoencephalopathy with Cysts and Calcification (LCC)
We describe the typical computed tomography (CT) and magnetic resonance imaging (MRI) characteristics in a rare case of adult leukoencephalopathy with calcifications and cysts (LCC). In addition, we describe t...
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Article
Imaging Patterns of Rhino-Orbital-Cerebral Mucormycosis in Immunocompromised Patients
The aim of this study was to describe radiological imaging findings of a complicated sinusitis, which should raise the suspicion of rhino-orbital-cerebral mucormycosis as being the underlying cause.
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Article
Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis
In search of novel germline alterations predisposing to tumors, in particular to gliomas, we studied a family with two brothers affected by anaplastic gliomas, and their father and paternal great-uncle diagnos...
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Article
Description and evaluation of operative deformity correction in calcium-deficiency rickets in Kaduna, northern Nigeria
Rickets is a recurrent disease worldwide, especially in countries with limited resources (Nield et al Am Fam Physician 74(4):619–626, 2006; Thacher et al Ann Trop Paediatr 26(1):1–16, 2006). Medical therapy inclu...
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Article
Open AccessAcute hemorrhagic leukoencephalitis (Weston-Hurst syndrome) in a patient with relapse-remitting multiple sclerosis
Acute hemorrhagic leukoencephalitis is a fulminant demyelinating disease and commonly considered as a rare and severe variant of acute disseminated encephalomyelitis. Here, we report the clinical, magnetic res...
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Article
Endoscopic intracranial surgery enhanced by electromagnetic-guided neuronavigation in children
Navigated intracranial endoscopy with conventional technique usually requires sharp head fixation. In children, especially in those younger than 1 year of age and in older children with thin skulls due to chro...
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Article
Electromagnetic navigation-guided surgery in the semi-sitting position for posterior fossa tumours: a safety and feasibility study
Electromagnetic (EM)-guided neuronavigation is an innovative technique and a viable alternative to opto-electric navigation. We have performed a safety and feasibility study using EM-guided neuronavigation for...
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Article
Open AccessAnti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography
Pathogenic autoantibodies targeting the recently identified leucine rich glioma inactivated 1 protein and the subunit 1 of the N-methyl-D-aspartate receptor induce autoimmune encephalitis. A comparison of brai...
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Article
Biphasic bone substitute and fibrin sealant for treatment of benign bone tumours and tumour-like lesions
Bone defects resulting from tumour resection or curettage are most commonly reconstructed with autologous bone graft which is associated with limited availability and donor site morbidity. Recent research has ...
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Article
The effect of common carotid artery occlusion on delayed brain tissue damage in the rat double subarachnoid hemorrhage model
Delayed ischemic brain tissue damage in the time course of cerebral vasospasm in the rat double-subarachnoid hemorrhage (SAH) model has been described before. However, in order to enhance hemodynamic insuffici...
