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  1. No Access

    Article

    Hydrogen bonding and biological specificity analysed by protein engineering

    The role of complementary hydrogen bonding as a determinant of biological specificity has been examined by protein engineering of the tyrosyl-tRNA synthetase. Deletion of a side chain between enzyme and substr...

    Alan R. Fersht, Jian-** Shi, Jack Knill-Jones, Denise M. Lowe… in Nature (1985)

  2. No Access

    Article

    Amplification and altered expression of the c-myc oncogene in A-MuLV-transformed fibroblasts

    Chromosomal rearrangements involving the c-myc oncogene are a prevalent feature of plasmacytomas that arise after inoculating BALB/c mice with pristane and Abelson murine leukaemia virus (A-MuLV)1–3. With this ob...

    Alain Nepveu, Paul D. Fahrlander, Jian-Qing Yang, Kenneth B. Marcu in Nature (1985)

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    Article

    Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

    HEPATITIS B virus (HBV) DNA frequently integrates into the genome of human primary liver cancer cells1–4, but the significance of this integration in liver carcinogenesis is still unclear. Here we report the clon...

    Jian Wang, Xavier Chenivesse, Berthold Henglein, Christian Bréchot in Nature (1990)

  4. No Access

    Article

    Rapid neutrophil adhesion to activated endothelium mediated by GMP-140

    GRANULE membrane protein-140 (GMP-140), a membrane glycoprotein of platelet1–5 and endothelial cell6–8 secretory granules, is rapidly redistributed to the plasma membrane during cellular activation and degranulat...

    Jian-Guo Geng, Michael P. Bevilacquat, Kevin L. Moore, Thomas M. Mclntyre… in Nature (1990)

  5. No Access

    Article

    C-terminal truncated glucose transporter is locked into an inward-facing form without transport activity

    THE facilitated glucose transporters comprise a structurally related family of proteins predicted to have 12 membrane-spanning domains, with the amino terminus, a relatively large middle loop and the carboxy-t...

    Yoshitomo Oka, Tomoichiro Asano, Yoshikazu Shibasaki, Jiann-Liang Lin… in Nature (1990)

  6. No Access

    Article

    One neuron, many units?

    Larry Cohen, Jian-young Wu in Nature (1990)

  7. No Access

    Article

    Revised projection of future greenhouse warming

    FOR the Intergovernmental Panel on Climate Change (IPCC) report1, using a simple climate/ocean model, we made projections of the greenhouse warming to 2100. Projections were made for four greenhouse-gas scenarios...

    Michael E. Schiesinger, **ngjian Jiang in Nature (1991)

  8. No Access

    Article

    Dependence of Ypt1 and Sec4 membrane attachment on Bet2

    MANY small GTP-binding proteins are synthesized as soluble proteins that are post-translationally modified as a prerequisite for membrane attachment1. Ypt1 and Sec4 are homologous Ras-like GTP-binding proteins th...

    Guendalina Rossi, Yu Jiang, Anna P. Newman, Susan Ferro-Novick in Nature (1991)

  9. No Access

    Article

    Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA

    SPLICING of pre-messenger RNA in eukaryotic cells occurs in a multicomponent complex termed the spliceosome, which contains small nuclear ribonucleoprotein particles (snRNPs), protein fac-tors and substrate pr...

    Jian Wu, James L. Manley in Nature (1991)

  10. No Access

    Article

    A Met-to-Val mutation in the skeletal muscle Na+ channel α-subunit in hyperkalaemic periodic paralysis

    HYPERKALAEMIC periodic paralysis (HYPP)1 is an autosomal dominant disease that results in episodic electrical inexcitability and paralysis of skeletal muscle. Electrophysiological data indicate that tetrodotoxin-...

    Cecilia V. Rojas, Jianzhou Wang, Lisa S. Schwartz, Eric P. Hoffman… in Nature (1991)

  11. No Access

    Article

    Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations

    AIDS, caused by human immunodeficiency virus (HIV), is one of the world's most serious health problems, with current protocols being inadequate for either prevention or successful long-term treatment. In retro...

    Edward Arnold, Alfredo Jacobo-Molina, Raymond G. Nanni, Roger L. Williams… in Nature (1992)

  12. No Access

    Article

    Detection of TeV photons from the active galaxy Markarian 421

    PHOTONS of TeV energy have been observed from a few sources in our Galaxy, notably the Crab Nebula1. We report here the detection of such photons from an extragalactic source, the giant elliptical galaxy Markaria...

    M. Punch, C. W. Akerlof, M. F. Cawley, M. Chantell, D. J. Fegan, S. Fennell… in Nature (1992)

  13. No Access

    Article

    Origin of luminescence from porous silicon deduced by synchrotron-light-induced optical luminescence

    FOLLOWING reports of intense optical luminescence from porous silicon1,2, the opportunity for engineering optoelectronic devices using this material3,4 has attracted considerable attention. At present, however, t...

    T. K. Sham, D. T. Jiang, I. Coulthard, J. W. Lorimer, X. H. Feng, K. H. Tan… in Nature (1993)

  14. Article

    HIV-1 inhibition by a peptide

    Shibo Jiang, Kang Lin, Nathan Strick, A. Robert Neurath in Nature (1993)

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  15. No Access

    Article

    Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

    VOLTAGE-GATED Ca2+ channels link changes in membrane potential to the delivery of Ca2+, a key second messenger for many cellular responses1. Ca2+ channels show selectivity for Ca2+ over more plentiful ions such a...

    Jian Yang, Patrick T. Elllnor, William A. Sather, JI-Fang Zhang, Richard W. Tsien in Nature (1993)

  16. No Access

    Article

    Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p

    THREE different prenyltransferases have been identified in yeast and higher cells1–6, the farnesyltransferase and the type I and type II geranylgeranyltransferases (GGTase). The farnesyltransferase and GGTase-I m...

    Yu Jiang, Guendalina Rossi, Susan Ferro-Novick in Nature (1993)

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    Article

    Functional ecdysone receptor is the product of EcR and Ultraspiracle genes

    ALTHOUGH the biological activity of the insect moulting hormone ecdysone, is manifested through a hormonally regulated transcriptional cascade associated with chromosomal puffing1–3, a direct association of the r...

    Tso-Pang Yao, Barry Marc Forman, Zeyu Jiang, Lucy Cherbas, J.-Don Chen… in Nature (1993)

  18. No Access

    Article

    Prediction of bone density from vitamin D receptor alleles

    BONE density achieved in early adulthood is the major determinant of risk of osteoporotic fracture. Up to 60% of women1,2 suffer osteoporotic fractures as a result of low bone density2, which is under strong gene...

    Nigel A. Morrison, Jian Cheng Qi, Akifumi Tokita, Paul J. Kelly, Linda Crofts… in Nature (1994)

  19. No Access

    Article

    A serine kinase regulates intracellular localization of splicing factors in the cell cycle

    SMALL nuclear ribonucleoprotein particles (snRNPs) and non-snRNP splicing factors containing a serine/arginine-rich domain (SR proteins) concentrate in ‘speckles’ in the nucleus of interphase cells1. It is believ...

    Jian-Fang Gui, William S. Lane, **ang-Dong Fu in Nature (1994)

  20. No Access

    Article

    A matrix metalloproteinase expressed on the surface of invasive tumour cells

    GELATINASE A (type-IV collagenase; Mr 72,000) is produced by tumour stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as t...

    Hiroshi Sato, Takahisa Takino, Yasunori Okada, Jian Cao, Akira Shinagawa… in Nature (1994)

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