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    Hydrogen bonding and biological specificity analysed by protein engineering

    The role of complementary hydrogen bonding as a determinant of biological specificity has been examined by protein engineering of the tyrosyl-tRNA synthetase. Deletion of a side chain between enzyme and substr...

    Alan R. Fersht, Jian-** Shi, Jack Knill-Jones, Denise M. Lowe… in Nature (1985)