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  1. No Access

    Article

    Physiologic Leg Bowing is not a Physiologic Condition but Instead is Associated with Vitamin D Disorders in Toddlers

    When children around 2-year-old show leg bowing without lower-limb radiographic abnormalities for rickets, the leg bowing is classified as “physiologic” genu varum without conducting a blood test. However, it ...

    Yuko Sakamoto, Muneaki Ishijima, Satoshi Nakano… in Calcified Tissue International (2020)

  2. No Access

    Article

    Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

    Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein—a mutation that confers reduced susceptibility to ba...

    Masaki Imai, Makoto Yamashita, Yuko Sakai-Tagawa… in Nature Microbiology (2020)

  3. No Access

    Article

    Association between leg bowing and serum alkaline phosphatase level regardless of the presence of a radiographic growth plate abnormality in pediatric patients with genu varum

    When children around 2 years of age show leg bowing and diseases are ruled out based on radiographic findings without conducting blood tests, they are classified as “physiologic” genu varum. Since whether or n...

    Yuko Sakamoto, Muneaki Ishijima, Mayuko Kinoshita… in Journal of Bone and Mineral Metabolism (2018)

  4. No Access

    Article

    Minimum Required Vitamin D Level for Optimal Increase in Bone Mineral Density with Alendronate Treatment in Osteoporotic Women

    Vitamin D insufficiency and deficiency are common in the elderly. Most previous studies using alendronate have used vitamin D supplementation regardless of individual vitamin D status. However, the minimum req...

    Muneaki Ishijima, Yuko Sakamoto, Makoto Yamanaka… in Calcified Tissue International (2009)

  5. No Access

    Article

    Association of oestrogen receptor gene polymorphism with the long-term results of rotational acetabular osteotomy

    Acetabular dysplasia (AD) contributes to the development of osteoarthritis of the hip. A rotational acetabular osteotomy (RAO) is one of the methods of pelvic osteotomy to prevent or treat secondary osteoarthr...

    Makoto Yamanaka, Muneaki Ishijima, Akifumi Tokita… in International Orthopaedics (2009)

  6. No Access

    Article

    Association of gene polymorphisms and bone density in Japanese girls

    Although some studies have reported a relationship between several candidate polymorphic genes and bone mineral density (BMD), little is known concerning the genetic factors influencing BMD in children. This ...

    Kiyoe Katsumata, Kyoko Nishizawa, Atsushi Unno… in Journal of Bone and Mineral Metabolism (2002)

  7. No Access

    Article

    Bioluminescent PCR-RFLP Enzyme-Linked Immunosorbent Assay for Analysis of Vitamin D Receptor Gene Polymorphism

    We developed a sensitive and rapid PCR-RFLP ELISA using acetate kinase (AK) and firefly luciferase as a detection system. AK used as a label enzyme could sensitively be detected by bioluminescent assay using t...

    Hidetoshi Arakawa, Amane Kokado, Shuzo Yoshizawa, Masako Maeda… in Analytical Sciences (1999)

  8. No Access

    Article

    Analysis of the stable levels of messenger RNA derived from different polymorphic alleles in the vitamin D receptor gene

    The association between polymorphisms in the vitamin D receptor (VDR) gene and bone mineral density (BMD) has been studied by many investigators. However, the question of how polymorphisms in the gene modulat...

    Masayo Yamagata, Shigeo Nakajima, Akifumi Tokita… in Journal of Bone and Mineral Metabolism (1999)

  9. Article

    Correction: Prediction of bone density from vitamin D raceptor alleles

    Nature 367, 284-287 (1994) .... In order to expand our original observations of a relationship between bone density and vitamin D receptor (VDR) genotype and to examine other genes potentially involved in bone...

    Nigel A. Morrison, Jian Cheng Qi, Akifumi Tokita, Paul J. Kelly, Linda Crofts… in Nature (1997)

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  10. No Access

    Article

    The role of vitamin D metabolites in the treatment of osteoporosis

    Roberto Civitelli M.D., Eturo Ogata, Louis V. Avioli… in Calcified Tissue International (1995)

  11. No Access

    Article

    Prediction of bone density from vitamin D receptor alleles

    BONE density achieved in early adulthood is the major determinant of risk of osteoporotic fracture. Up to 60% of women1,2 suffer osteoporotic fractures as a result of low bone density2, which is under strong gene...

    Nigel A. Morrison, Jian Cheng Qi, Akifumi Tokita, Paul J. Kelly, Linda Crofts… in Nature (1994)

  12. No Access

    Article

    Intestinal absorption of AACa in bile duct ligated rats

    Akifumi Tokita, Takeshi Maruyama, Toshio Mori… in Journal of Bone and Mineral Metabolism (1993)

  13. No Access

    Article

    Osteoporosis in a boy with hypogonadotropic hypogonadism

    We describe a 16-year-old boy with idiopathic hypogonadotropic hypogonadism associated with osteoporosis. Osteoporotic lesions of the hands, skull and spine were shown by routine radiography. Single-photon abs...

    Madoka Arisaka, Osamu Arisaka, Atsuto Hosaka… in Journal of Bone and Mineral Metabolism (1989)

  14. No Access

    Article

    Progressive vascular lesions in Williams-Beuren syndrome

    We report two patients with Williams-Beuren syndrome. The first patient showed no evidence of coarctation of the aorta at the first examination. Seven years later, she developed coarctation of the aorta. In th...

    Dr. Toshihiro Ino, Kei Nishimoto, Masazumi Iwahara, Katsumi Akimoto… in Pediatric Cardiology (1988)