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  1. Article

    Erratum: P-selectin primes leukocyte integrin activation during inflammation

    Nat. Immunol. 8, 882–892 (2007); published online 15 July 2007; corrected after print 13 November 2013 In the version of this article initially published, in Figure 4b the row labeled 'IB: α-PSGL-1 monomer' is...

    Hai-Bo Wang, **-Tao Wang, Lei Zhang, Zhen H Geng, Wei-Li Xu, Tao Xu… in Nature Immunology (2014)

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    Article

    Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection

    Evidence of crosstalk between the Robo/Slit and Wnt signalling pathways is provided, and R-spondin signalling is shown to enhance canonical Wnt signalling and increase the proliferation of intestinal stem cells.

    Wei-Jie Zhou, Zhen H. Geng, Jason R. Spence, Jian-Guo Geng in Nature (2013)

  3. Article

    Over-expression of Slit2 induces vessel formation and changes blood vessel permeability in mouse brain

    To investigate the effect of the axon guidance cue Slit2 on the density of blood vessels and permeability of the blood-brain barrier in mouse brain.

    Hai-xiong Han, Jian-guo Geng in Acta Pharmacologica Sinica (2011)

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  4. Article

    Erratum: Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis

    Correction to: Cell Research (2011) 21:609–626. doi:10.1038/cr.2011.17; published online 1 February 2011 The authors apologize for the misplacement of the upper right panel of Figure 1G. The correct panel of F...

    Wei-Jie Zhou, Zhen H Geng, Shan Chi, Wenli Zhang, **ao-Feng Niu… in Cell Research (2011)

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  5. Article

    Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis

    The Slit family of guidance cues binds to Roundabout (Robo) receptors and modulates cell migration. We report here that ectopic expression of Slit2 and Robo1 or recombinant Slit2 treatment of Robo1-expressing ...

    Wei-Jie Zhou, Zhen H Geng, Shan Chi, Wenli Zhang, **ao-Feng Niu… in Cell Research (2011)

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    Article

    Slit2 involvement in glioma cell migration is mediated by Robo1 receptor

    Slit and Robo proteins are evolutionarily conserved molecules whose interaction underlies axon guidance and neuronal precursor cell migration. During development secreted Slit proteins mediate chemorepulsive s...

    Sonja Mertsch, Nicole Schmitz, Astrid Jeibmann, Jian-Guo Geng… in Journal of Neuro-Oncology (2008)

  7. Article

    Andrographolide inhibits NF-κB activation and attenuates neointimal hyperplasia in arterial restenosis

    The NF-κB transcription factors modulate the expression of tissue factor (TF), E-selectin (CD62E) and vascular cell adhesion molecule-1 (VCAM-1), which are essential for thrombosis and inflammation. We have pr...

    Yu-Jiu Wang, **-Tao Wang, Quan-**n Fan, Jian-Guo Geng in Cell Research (2007)

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    Article

    P-selectin primes leukocyte integrin activation during inflammation

    Selectins mediate leukocyte rolling and prime leukocytes for integrin-mediated leukocyte adhesion. However, neither the in vivo importance of nor the signaling pathway by which selectin-mediated integrin activati...

    Hai-Bo Wang, **-Tao Wang, Lei Zhang, Zhen H Geng, Wei-Li Xu, Tao Xu… in Nature Immunology (2007)

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    Article

    P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis

    Stimulated endothelial cells and activated platelets express P-selectin (CD62P), a member of the selectin family of cell adhesion molecules, which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162...

    Ming Chen, Jian-Guo Geng in Archivum Immunologiae et Therapiae Experimentalis (2006)

  10. Article

    Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies

    Directional migration of leukocytes is indispensable to innate immunity for host defense. However, recruitment of leukocytes to a site of tissue injury also constitutes a leading cause for inflammatory respons...

    Jian Guo GENG in Cell Research (2001)

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  11. Article

    Partial characterization of the N-linked oligosaccharide structures on P-selectin glycoprotein ligand-1 (PSGL-1)

    PSGL-1, a specific ligand for P-, E- and L-selectin, was isolated from in vivo [3H]-glucosamine labeled HL-60 cells by a combination of wheat germ agglutinin-agarose and P- or E-selectin-agarose chromatography. N...

    Paul A AEED, Jian Guo GENG, Darwin ASA, Loretta RAYCROFT, Li MA… in Cell Research (2001)

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    Article

    Characterization of the O-linked oligosaccharide structures on P-selectin glycoprotein ligand-1 (PSGL-1)

    P-selectin glypoprotein ligand-1, PSGL-1, a specific ligand for P-, E-, and L-selectin, was isolated from in vivo [3H]-glucosamine labeled HL-60 cells by a combination of wheat germ agglutinin and platelet P-s...

    Paul A. Aeed, Jian-Guo Geng, Darwin Asa, Loretta Raycroft, Li Ma… in Glycoconjugate Journal (1998)

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    Article

    Rapid neutrophil adhesion to activated endothelium mediated by GMP-140

    GRANULE membrane protein-140 (GMP-140), a membrane glycoprotein of platelet1–5 and endothelial cell6–8 secretory granules, is rapidly redistributed to the plasma membrane during cellular activation and degranulat...

    Jian-Guo Geng, Michael P. Bevilacquat, Kevin L. Moore, Thomas M. Mclntyre… in Nature (1990)