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Article
Open AccessSocial and psychological adversity are associated with distinct mother and infant gut microbiome variations
Health disparities are driven by underlying social disadvantage and psychosocial stressors. However, how social disadvantage and psychosocial stressors lead to adverse health outcomes is unclear, particularly ...
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Article
Open AccessLongitudinal gut virome analysis identifies specific viral signatures that precede necrotizing enterocolitis onset in preterm infants
Necrotizing enterocolitis (NEC) is a serious consequence of preterm birth and is often associated with gut bacterial microbiome alterations. However, little is known about the development of the gut virome in ...
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Article
Open AccessDiscordant transmission of bacteria and viruses from mothers to babies at birth
The earliest microbial colonizers of the human gut can have life-long consequences for their hosts. Precisely how the neonatal gut bacterial microbiome and virome are initially populated is not well understood...
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Article
Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome
Hospitalized preterm infants receive frequent and often prolonged exposures to antibiotics because they are vulnerable to infection. It is not known whether the short-term effects of antibiotics on the preterm...
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Article
Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice
The relationship between assembly of the gut community and gut mucosal immunoglobulin A responses during the first 24–36 months of postnatal life in a cohort of 40 twin pairs is defined and modelled in gnotobi...
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Article
Early life dynamics of the human gut virome and bacterial microbiome in infants
Colonization of the infant gut by viruses, bacteriophages and bacteria over the first two years of life.
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Article
Open AccessErratum: Gut resistome development in healthy twin pairs in the first year of life
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Article
Open AccessGut resistome development in healthy twin pairs in the first year of life
The early life of the human host marks a critically important time for establishment of the gut microbial community, yet the developmental trajectory of gut community-encoded resistance genes (resistome) is un...
