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Open AccessPrenatal exposure to maternal disadvantage-related inflammatory biomarkers: associations with neonatal white matter microstructure
Prenatal exposure to heightened maternal inflammation has been associated with adverse neurodevelopmental outcomes, including atypical brain maturation and psychiatric illness. In mothers experiencing socioeco...
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Article
Open AccessSocial and psychological adversity are associated with distinct mother and infant gut microbiome variations
Health disparities are driven by underlying social disadvantage and psychosocial stressors. However, how social disadvantage and psychosocial stressors lead to adverse health outcomes is unclear, particularly ...
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Open AccessSocial disadvantage during pregnancy: effects on gestational age and birthweight
Whether psychosocial adversity during pregnancy impacts fetal health outcomes at birth remains underexplored. This is a critical issue given significant social disadvantage and psychosocial stress faced by pre...
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Open AccessLongitudinal gut virome analysis identifies specific viral signatures that precede necrotizing enterocolitis onset in preterm infants
Necrotizing enterocolitis (NEC) is a serious consequence of preterm birth and is often associated with gut bacterial microbiome alterations. However, little is known about the development of the gut virome in ...
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The progression of serum cystatin C concentrations within the first month of life after preterm birth—a worldwide systematic review
Multiple single-center studies have examined the progression of kidney function biomarkers such as serum cystatin C (Cys C) in the first 30 days of life (DOL) after preterm birth, but from different ethnicitie...
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Factors associated with progression to infection in methicillin-resistant Staphylococcus aureus-colonized, critically ill neonates
To identify factors associated with development of symptomatic infection in infants colonized with methicillin-resistant Staphylococcus aureus (MRSA) in the Neonatal Intensive Care Unit (NICU).
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Open AccessDiscordant transmission of bacteria and viruses from mothers to babies at birth
The earliest microbial colonizers of the human gut can have life-long consequences for their hosts. Precisely how the neonatal gut bacterial microbiome and virome are initially populated is not well understood...
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Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome
Hospitalized preterm infants receive frequent and often prolonged exposures to antibiotics because they are vulnerable to infection. It is not known whether the short-term effects of antibiotics on the preterm...
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Open AccessDeterminants of Initial Antibiotic Duration in Very Low Birth Weight Neonates
Very low birth weight (VLBW) neonates (< 1500 g) are commonly exposed to prolonged antibiotic courses related to concerns for presumed early onset sepsis often with unclear indications. While antibiotics can b...
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Article
The contribution of the gut microbiome to neurodevelopment and neuropsychiatric disorders
Bidirectional communication between the gut and brain is well recognized, with data now accruing for a specific role of the gut microbiota in that link, referred to as the microbiome–gut–brain axis. This revie...
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Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes
Commensal gut bacterial communities (microbiomes) are predicted to influence human health and disease1,2. Neonatal gut microbiomes are colonized with maternal and environmental flora and mature toward a stable co...
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Open AccessIntestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis
Necrotizing enterocolitis (NEC) is a catastrophic disease of preterm infants, and microbial dysbiosis has been implicated in its pathogenesis. Studies evaluating the microbiome in NEC and preterm infants lack ...
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Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice
The relationship between assembly of the gut community and gut mucosal immunoglobulin A responses during the first 24–36 months of postnatal life in a cohort of 40 twin pairs is defined and modelled in gnotobi...
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Developmental dynamics of the preterm infant gut microbiota and antibiotic resistome
Development of the preterm infant gut microbiota is emerging as a critical research priority1. Since preterm infants almost universally receive early and often extended antibiotic therapy2, it is important to und...
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Early life dynamics of the human gut virome and bacterial microbiome in infants
Colonization of the infant gut by viruses, bacteriophages and bacteria over the first two years of life.
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Open AccessErratum: Gut resistome development in healthy twin pairs in the first year of life
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Open AccessGut resistome development in healthy twin pairs in the first year of life
The early life of the human host marks a critically important time for establishment of the gut microbial community, yet the developmental trajectory of gut community-encoded resistance genes (resistome) is un...
