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  1. Article

    Open Access

    HIV-associated gut microbial alterations are dependent on host and geographic context

    HIV-associated changes in intestinal microbiota are believed to be important drivers of disease progression. However, the majority of studies have focused on populations in high-income countries rather than in...

    Muntsa Rocafort, David B. Gootenberg, Jesús M. Luévano Jr. in Nature Communications (2024)

  2. Article

    Open Access

    The history and organization of the Workshop on Population and Speciation Genomics

    With the advent of high-throughput genome sequencing, bioinformatics training has become essential for research in evolutionary biology and related fields. However, individual research groups are often not in ...

    Julia M. I. Barth, Scott A. Handley, Daniel Kintzl in Evolution: Education and Outreach (2023)

  3. Article

    Open Access

    Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

    Omicron variant strains encode large numbers of changes in the spike protein compared to historical SARS-CoV-2 isolates. Although in vitro studies have suggested that several monoclonal antibody therapies lose...

    James Brett Case, Samantha Mackin, John M. Errico, Zhenlu Chong in Nature Communications (2022)

  4. Article

    In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

    Rapidly emerging SARS-CoV-2 variants jeopardize antibody-based countermeasures. Although cell culture experiments have demonstrated a loss of potency of several anti-spike neutralizing antibodies against varia...

    Rita E. Chen, Emma S. Winkler, James Brett Case, Ishmael D. Aziati in Nature (2021)

  5. Article

    Author Correction: Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes

    Ya-Ting Wang, Konstantin Zaitsev, Qun Lu, Shan Li in Nature Microbiology (2021)

  6. No Access

    Article

    Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes

    Innate and adaptive immune responses that prime myeloid cells, such as macrophages, protect against pathogens1,2. However, if left uncontrolled, these responses may lead to detrimental inflammation3. Macrophages,...

    Ya-Ting Wang, Konstantin Zaitsev, Qun Lu, Shan Li in Nature Microbiology (2020)

  7. Article

    Open Access

    Discordant transmission of bacteria and viruses from mothers to babies at birth

    The earliest microbial colonizers of the human gut can have life-long consequences for their hosts. Precisely how the neonatal gut bacterial microbiome and virome are initially populated is not well understood...

    Rabia Maqsood, Rachel Rodgers, Cynthia Rodriguez, Scott A. Handley in Microbiome (2019)

  8. Article

    Open Access

    The virome: a missing component of biological interaction networks in health and disease

    Host-associated viral populations, viromes, have been understudied relative to their contribution to human physiology. Viruses interact with host gene networks, influencing both health and disease. Analysis of...

    Scott A. Handley in Genome Medicine (2016)