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  1. Article

    Open Access

    Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance

    Tetracycline resistance by antibiotic inactivation was first identified in commensal organisms but has since been reported in environmental and pathogenic microbes. Here, we identify and characterize an expand...

    Andrew J. Gasparrini, Jana L. Markley, Hirdesh Kumar, Bin Wang… in Communications Biology (2020)

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  2. No Access

    Article

    Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome

    Hospitalized preterm infants receive frequent and often prolonged exposures to antibiotics because they are vulnerable to infection. It is not known whether the short-term effects of antibiotics on the preterm...

    Andrew J. Gasparrini, Bin Wang, **aoqing Sun, Elizabeth A. Kennedy… in Nature Microbiology (2019)

  3. No Access

    Article

    Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes

    Structural and functional characterization of tetracycline-inactivating enzymes reveals that inhibitors act by locking the enzyme in an unproductive state by restricting substrate-driven conformational dynamic...

    Jooyoung Park, Andrew J Gasparrini, Margaret R Reck… in Nature Chemical Biology (2017)

  4. No Access

    Article

    Next-generation approaches to understand and combat the antibiotic resistome

  5. The anthropogenic use of antibiotics has selected for an increase in the evolution and dissemination of antibiotic resistance in environmental and human-associ...

    6. Terence S. Crofts, Andrew J. Gasparrini, Gautam Dantas in Nature Reviews Microbiology (2017)