162 Result(s)
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Open AccessVimentin-mediated buffering of internal integrin β1 pool increases survival of cells from anoikis
The intermediate filament protein vimentin is widely recognized as a molecular marker of epithelial-to-mesenchymal transition. Although vimentin expression is strongly associated with cancer metastatic potenti...
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Open AccessGenoMycAnalyzer: a web-based tool for species and drug resistance prediction for Mycobacterium genomes
Drug-resistant tuberculosis (TB) is a major threat to global public health. Whole-genome sequencing (WGS) is a useful tool for species identification and drug resistance prediction, and many clinical laborator...
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Open AccessAuthor Correction: Versatile spaceborne photonics with chalcogenide phase-change materials
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Dual suppressive effect of p-coumaric acid on pigmentation in B16F10 cells
Hyperpigmentation, frequently triggered by an excessive production of melanin, is a common issue within the realms of dermatology and cosmetology. In addition to regulating tyrosinase activity, the autophagy p...
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Open AccessVersatile spaceborne photonics with chalcogenide phase-change materials
Recent growth in space systems has seen increasing capabilities packed into smaller and lighter Earth observation and deep space mission spacecraft. Phase-change materials (PCMs) are nonvolatile, reconfigurabl...
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Open AccessTRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma
The ubiquitin-proteasome system is a vital protein degradation system that is involved in various cellular processes, such as cell cycle progression, apoptosis, and differentiation. Dysregulation of this syste...
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Correction: Comprehensive metagenomic analysis of stress‑resistant and‑sensitive Listeria monocytogenes
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Comprehensive metagenomic analysis of stress-resistant and -sensitive Listeria monocytogenes
Listeria monocytogenes is a pathogenic bacterium which can live in adverse environments (low pH, high salinity, and low temperature). Even though there are various whole genome sequencing (WGS) data on L. monocyt...
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Open AccessPeptidylarginine deiminase 2 plays a key role in osteogenesis by enhancing RUNX2 stability through citrullination
Peptidylarginine deiminase (PADI) 2 catalyzes the post-translational conversion of peptidyl-arginine to peptidyl-citrulline in a process called citrullination. However, the precise functions of PADI2 in bone f...
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Open AccessRepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter
Megakaryocytes (MKs) are platelet precursors, which arise from hematopoietic stem cells (HSCs). While MK lineage commitment and differentiation are accompanied by changes in gene expression, many factors that ...
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Open AccessMelatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR
The physiological crosstalk between glucocorticoid and melatonin maintains neuronal homeostasis in regulating circadian rhythms. However, the stress-inducing level of glucocorticoid triggers mitochondrial dysf...
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Protocol
In Vitro Morphogenesis and Differentiation of Human Intestinal Epithelium in a Gut-on-a-Chip
The establishment of a three-dimensional (3D ) epithelial structure and cytodifferentiation in vitro is necessary to recapitulate in vivo-relevant structure and function of the human intestine. Here, we descri...
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3-Hydroxymorphinan protects against hypoxia-induced cell death in primary astrocyte by regulating Ca2+ influx and the glutamate homeostasis
Hypoxia is a pathological phenomenon of the central nervous system that occurs during ischemia and stroke, leading to brain cell damage. Astrocytes play an important role in maintaining homeostasis in the brai...
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Protocol
Quantification of Golgi Entry and Exit Kinetics of Protein Cargoes
The Golgi apparatus is a pivotal secretory organelle in membrane trafficking, a hub responsible for posttranslational modifications, sorting, and trafficking of newly synthetized proteins received from the end...
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Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling
Adherens junctions (AJs) create spatially, chemically and mechanically discrete microdomains at cellular interfaces. Here, using a mechanogenetic platform that generates artificial AJs with controlled protein ...
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Open AccessCharacterization of Domestication Loci Associated with Awn Development in Rice
Rice (Oryza sativa L.) is a widely studied domesticated model plant. Seed awning is an unfavorable trait during rice harvesting and processing. Hence, loss of awn was one of the target characters selected during...
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Open AccessRetraction Note to: Expansion of monocytic myeloid-derived suppressor cells ameliorated intestinal inflammatory response by radiation through SOCS3 expression
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Open AccessDepth image conversion model based on CycleGAN for growing tomato truss identification
On tomato plants, the flowering truss is a group or cluster of smaller stems where flowers and fruit develop, while the growing truss is the most extended part of the stem. Because the state of the growing tru...
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Characterization of bacterial community structure in two alcyonacean soft corals (Litophyton sp. and Sinularia sp.) from Chuuk, Micronesia
Microbes in the coral holobiont play important roles in nitrogen fixation, carbon supply, antibiotic production, mucus recycling, and food supply to maintain homeostasis in corals. However, microbes can also i...
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Open AccessPrenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2–neuronal FGFR1 axis
Exposure to maternal stress irreversibly impairs neurogenesis of offspring by inducing life-long effects on interaction between neurons and glia under raging differentiation process, culminating in cognitive a...