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Article
Open AccessVimentin-mediated buffering of internal integrin β1 pool increases survival of cells from anoikis
The intermediate filament protein vimentin is widely recognized as a molecular marker of epithelial-to-mesenchymal transition. Although vimentin expression is strongly associated with cancer metastatic potenti...
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Article
Digestive enzyme supplementation in prescription drugs, over-the-counter drugs, and enzyme foods
Digestive enzyme supplements are used in various fields, including prescription drugs, over-the-counter drugs, and enzyme foods, but few comprehensively organized data are available. In addition, the classific...
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Article
Development and evaluation of a digestive formulation using a microbial enzyme for treatment of dyspepsia
A digestive enzyme is prepared as a treatment for dyspepsia by aiding in the breakdown of food, and its representative ingredient is porcine pancreatin. This study aims to develop a fast and effective digestiv...
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Article
Open AccessMachine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials
Thrombotic microangiopathy-induced thrombocytopenia-associated multiple organ failure and hyperinflammatory macrophage activation syndrome are important causes of late pediatric sepsis mortality that are often mi...
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Open AccessAuthor Correction : SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease
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Article
Open AccessPrevalence of Pathogenic and Potentially Pathogenic Inborn Error of Immunity Associated Variants in Children with Severe Sepsis
Our understanding of inborn errors of immunity is increasing; however, their contribution to pediatric sepsis is unknown.
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Article
Open AccessSUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease
Huntington’s disease (HD) is a severe inherited neurological disorder caused by a CAG repeat expansion in the huntingtin gene (HTT), leading to the accumulation of mutant huntingtin with polyglutamine repeats. De...
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Article
Effect of Epidermal Growth Factor on the Colony-formation Ability of Porcine Spermatogonial Germ Cells
Spermatogonial stem cells (SSCs) are crucial for maintaining spermatogenesis, studying germ line stem cell biology, and producing transgenic animals. Growth factors, including leukemia inhibitory factor (LIF),...
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Article
Open AccessCollective effects of long-range DNA methylations predict gene expressions and estimate phenotypes in cancer
DNA methylation of various genomic regions has been found to be associated with gene expression in diverse biological contexts. However, most genome-wide studies have focused on the effect of (1) methylation in c...
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Article
Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats
To examine the anti-obesity effects of ginsenosides in Korea Red Ginseng (KRG, Panax ginseng) in rats fed with a high-fat diet (HFD).
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Article
Open AccessCD14 is a unique membrane marker of porcine spermatogonial stem cells, regulating their differentiation
Molecular markers of spermatogonia are necessary for studies on spermatogonial stem cells (SSCs) and improving our understanding of molecular and cellular biology of spermatogenesis. Although studies of germ c...
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Article
Sorption of Pb in chemical and particle-size fractions of soils with different physico-chemical properties
Lead (Pb) sorption capacity (PbSmax) and distribution in chemical and particle-size fractions of six soils with different physico-chemical properties were investigated to explore the principal properties of soils...
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Article
A 4-Axis Technique for Three-Dimensional Printing of an Artificial Trachea
Several types of three-dimensional (3D)-printed tracheal scaffolds have been reported. Nonetheless, most of these studies concentrated only on application of the final product to an in vivo animal study and could...
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Article
Open AccessAnti-cancer activity of Angelica gigas by increasing immune response and stimulating natural killer and natural killer T cells
The polysaccharide component of Angelica gigas induces immuno-stimulatory effects on innate immune cells. However, it is unclear whether A. gigas’ adjuvant activity on the immune system can elicit anti-cancer res...
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Article
Open AccessGraphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model
Graphene oxide (GO) modulates the functions of antigen-presenting cells including dendritic cells (DCs). Although carbon nanotubes affect expression of the MHC class I-like CD1d molecule, whether GO can influe...
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Article
Expression of Insulin-like Growth Factor Binding Protein-3 and Regulation of the Insulin-like Growth Factor-I Axis in Pig Testis
The stem cell niche is a complex unit comprising key components, such as the extracellular matrix and various paracrine factors, which regulate the differentiation of adult stem cells. In our previous study, w...
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Article
3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
Widespread mRNA 3′ UTR shortening through alternative polyadenylation 1 promotes tumor growth in vivo 2 . A prevailing hypothesis is that it in...
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Article
Open AccessAnti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats
Human placenta hydrolysate (hPH) has been utilized to improve menopausal, fatigue, liver function. Its high concentration of bioactive substances is known to produce including antioxidant, anti-inflammatory an...
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Article
Open AccessMicroplasma Jet Arrays as a Therapeutic Choice for Fungal Keratitis
The clinical impact of microplasma jets on rabbit eyes infected by Candida albicans has been investigated. Arrays of such jets produce low-temperature plasma micro-columns suitable for ophthalmic therapeutics and...
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Article
The Effect of Trait Emotional Intelligenceon the Relationship Between Dispositional Mindfulness and Self-esteem
The objective of this study is to analyze the mediating effect of emotional intelligence (EI) on the relationship between mindfulness and self-esteem. A survey involving 234 subjects was based on self-administ...
