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Article
Open AccessPeptidylarginine deiminase 2 plays a key role in osteogenesis by enhancing RUNX2 stability through citrullination
Peptidylarginine deiminase (PADI) 2 catalyzes the post-translational conversion of peptidyl-arginine to peptidyl-citrulline in a process called citrullination. However, the precise functions of PADI2 in bone f...
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Article
Open AccessNicotinamide enhances osteoblast differentiation through activation of the mitochondrial antioxidant defense system
Although the normal physiological level of oxidative stress is beneficial for maintaining bone homeostasis, imbalance between reactive oxygen species (ROS) production and antioxidant defense can cause various ...
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Article
Open AccessSeptal chondrocyte hypertrophy contributes to midface deformity in a mouse model of Apert syndrome
Midface hypoplasia is a major manifestation of Apert syndrome. However, the tissue component responsible for midface hypoplasia has not been elucidated. We studied mice with a chondrocyte-specific Fgfr2S252W muta...
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Article
Open AccessBlood-testis barrier integrity depends on Pin1 expression in Sertoli cells
The conformation and function of a subset of serine and threonine-phosphorylated proteins are regulated by the prolyl isomerase Pin1 through isomerization of phosphorylated Ser/Thr-Pro bonds. Pin1 is intensely...
