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Article
Controlling the biodistribution and clearance of nanomedicines
Nanomedicines improve drug bioavailability, the dose–response relationship, targeting ability, efficacy and safety compared to conventional freely administered drugs. Nonetheless, despite their success as carr...
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Article
Open AccessPolymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models
Nano-immunotherapy improves breast cancer outcomes but not all patients respond and none are cured. To improve efficacy, research focuses on drugs that reprogram cancer-associated fibroblasts (CAFs) to improve...
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Chapter
RNA/Polymer-Based Supramolecular Approaches for mRNA Delivery
Messenger RNA (mRNA) therapeutics garner growing attention, especially after the approval of two mRNA vaccine formulations for COVID-19. Meanwhile, as a therapeutic modality, mRNA still has issues of poor bioa...
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Chapter
Abnormal Glycosylation in Cancer Cells and Cancer Stem Cells as a Therapeutic Target
Tumor resistance and recurrence have been associated with the presence of cancer stem cells (CSCs) in tumors. The functions and survival of the CSCs have been associated with several intracellular and extracel...
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Article
Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma
Because of the blood–tumour barrier and cross-reactivity with healthy tissues, immune checkpoint blockade therapy against glioblastoma has inadequate efficacy and is associated with a high risk of immune-relat...
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Article
Erythrocyte depletion lifts nanoparticle half-lives
The partial depletion of red blood cells via the administration of a low dose of anti-erythrocyte antibodies increases the circulation half-life of nanomedicines, as shown in rodent models of cancer.
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Article
Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges
Multiple nanotherapeutics have been approved for patients with cancer, but their effects on survival have been modest and, in some examples, less than those of other approved therapies. At the same time, the c...
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Article
Open AccessIn vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Stabilisation of fragile oligonucleotides, typically small interfering RNA (siRNA), is one of the most critical issues for oligonucleotide therapeutics. Many previous studies encapsulated oligonucleotides into...
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Article
A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy
Engineered nanoparticles that respond to pathophysiological parameters, such as pH or redox potential, have been developed as contrast agents for the magnetic resonance imaging (MRI) of tumours. However, beyon...
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Article
Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery
The enhanced extravasation of nanoparticles from tumour blood vessels into the tumour interstitial space has been found to be due to dynamic vents that form transient openings and closings at leaky blood vesse...
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Article
In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent
A more immediate impact for therapeutic approaches of current clinical research efforts is of major interest, which might be obtained by develo** a noninvasive radiation dose-escalation strategy, and neutron...
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Chapter
Intravital Real-Time Confocal Laser Scanning Microscopy for the In Situ Evaluation of Nanocarriers
Visualization of drug/gene nanocarriers within living tissue is essential for optimization towards clinical applications. In this regard, we have established an intravital real-time confocal laser scanning mic...
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Chapter
Bridging Polymer Science and Medicine Through Supramolecular Nanoassemblies
Boundaries between synthetic polymers and biology are disappearing as an increasing number of manmade macromolecular constructs take a central role in biological processes. The research in this area has been c...
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Article
Nanopolymeric Therapeutics
Polymers have been extensively utilized in the design of nanometer-sized delivery vehicles of chemotherapeutics for clinical cancer therapy. Polymeric nanoparticulate delivery vehicles, with chemotherapeutics ...
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Article
A Photo-Activated Targeting Chemotherapy Using Glutathione Sensitive Camptothecin-Loaded Polymeric Micelles
A novel photo-activated targeted chemotherapy was developed by photochemical internalization (PCI) of glutathione-sensitive polymeric micelles incorporating camptothecin (CPT) prepared from thiolated CPT (CPT-...
