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Article
A novel intranasal peptide vaccine inhibits non-small cell lung cancer with KRAS mutation
KRAS mutations occur commonly in the lung and can lead to the development of non-small cell lung cancer (NSCLC). While the mutated KRAS protein is a neoantigen, it usually does not generate an effective anti-t...
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Article
Open AccessMulticomponent intranasal adjuvant for mucosal and durable systemic SARS-CoV-2 immunity in young and aged mice
Multiple FDA-approved SARS-CoV-2 vaccines currently provide excellent protection against severe disease. Despite this, immunity can wane relatively fast, particularly in the elderly and novel viral variants ca...
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Article
Open AccessFunctionalized nanoparticles with targeted antibody to enhance imaging of breast cancer in vivo
Targeted contrast nanoparticles for breast tumor imaging facilitates early detection and improves treatment efficacy of breast cancer. This manuscript reports the development of an epidermal growth factor rece...
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Article
Open AccessAddendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel
Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institut...
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Article
Infliximab for Treatment of Granulomatous Disease in Patients with Common Variable Immunodeficiency
Eight to 22 % of common variable immunodeficiency (CVID) patients exhibit granulomas of the lungs, spleen, liver, and/or skin. Granulomas can be the most medically significant day-to-day problem for CVID patie...
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Article
Open AccessOverexpression of BID in thyroids of transgenic mice increases sensitivity to iodine-induced autoimmune thyroiditis
BID functions as a bridge molecule between death-receptor and mitochondrial related apoptotic pathways to amplify apoptotic signaling. Our previous studies have demonstrated a substantial increase in BID expre...
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Article
Erratum: Applications of nanotechnology for immunology
Nature Reviews Immunology 13, 592–605 (2013) In the version of this Review that was initially published, the reference citations in Tables 1–3 were not accurate. This error has been corrected in the online HTM...
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Article
Applications of nanotechnology for immunology
Nanotechnology makes use of the unique properties of objects that function as a unit within the overall size range of 1 to 1,000 nanometres, which is on the sa...
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Article
Sustained Analgesia Achieved Through Esterase-Activated Morphine Prodrugs Complexed with PAMAM Dendrimer
Design and evaluate the in vitro and in vivo efficacy of two extended release morphine formulations developed for IV administration by complexing esterase activated morphine prodrugs to surface-modified, generati...
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Article
Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate
Nanoparticle (NP)-based targeted drug delivery involves cell-specific targeting followed by a subsequent therapeutic action from the therapeutic carried by the NP system. NPs conjugated with methotrexate (MTX)...
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Chapter
Dendrimer-Based Nanoparticle Therapies: Can Uniform Multifunctional Therapeutics Be Made with Current Chemical Approaches?
The development of multifunctional, dendrimer-based therapeutics has been a major focus of the Michigan Nanotechnology Institute for Medicine and Biological Sciences (MNIMBS) over the past 15 years. Based on t...
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Article
Imaging of gold dendrimer nanocomposites in cells
Dendrimer nanocomposites (DNC) are hybrid nanoparticles formed by the dispersion and immobilization of guest atoms or small clusters in dendrimer matrices. They have a great potential in biomedical application...
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Article
Nanopolymeric Therapeutics
Polymers have been extensively utilized in the design of nanometer-sized delivery vehicles of chemotherapeutics for clinical cancer therapy. Polymeric nanoparticulate delivery vehicles, with chemotherapeutics ...
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Article
Control of Two-photon Fluorescence of Common Dyes and Conjugated Dyes
We present a comprehensive study of the selective excitation of two-photon fluorescence from various pairs of dyes and dyes in different conjugation states with tailored pulse shapes found with a genetic algor...
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Chapter
Nanotechnology for Biology and Medicine
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Article
Labeling Cells with Silver/Dendrimer Nanocomposites
We have developed water-soluble, biocompatible, fluorescent, and photostable silver/dendrimer nanocomposites that have a potential to be used for in vitro cell labeling. A PAMAM_E5.NH2 dendrimer was used as a tem...
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Article
IFNγ sensitization to TRAIL-induced apoptosis in human thyroid carcinoma cells by upregulating Bak expression
TRAIL preferentially induces apoptosis in tumor cells and virus-infected cells. Unlike other tumor necrosis factor family members, TRAIL does not kill cells from most normal tissues and has thus been proposed ...
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Protocol
Dendrimer-Mediated Cell Transfection in Vitro
In recent years, Starburst® PAMAM dendrimers, a class of polyamidoamine polymers, have become an interesting alternative vector for nonviral delivery of DNA in vitro and in vivo (1-6). These nanoscopic polymers, ...
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Article
The fungicidal activity of novel nanoemulsion (X8W60PC) against clinically important yeast and filamentous fungi
Surfactant nanoemulsions are water in oil preparations that proved to have a broad spectrum biocidal activity against a variety of microorganisms including Gram-positive and Gram-negative bacteria, spores and ...
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Article
Imaging {Au0-PAMAM} Gold-dendrimer Nanocomposites in Cells
Dendrimer nanocomposites (DNC) are hybrid nanoparticles formed by the dispersion and immobilization of guest atoms or small clusters in dendritic polymer matrices. They have a great potential in biomedical app...
