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    Article

    Free-stream receptivity of a hypersonic blunt cone using input–output analysis and a shock-kinematic boundary condition

    Traditional stability tools have done much in the last few decades to demonstrate the significance of modal instabilities as a pathway for laminar to turbulent transition in hypersonic flows, but are less effe...

    David A. Cook, Joseph W. Nichols in Theoretical and Computational Fluid Dynamics (2022)

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    Article

    Stability and modal analysis of shock/boundary layer interactions

    The dynamics of oblique shock wave/turbulent boundary layer interactions is analyzed by mining a large-eddy simulation (LES) database for various strengths of the incoming shock. The flow dynamics is first ana...

    Joseph W. Nichols, Johan Larsson in Theoretical and Computational Fluid Dynami… (2017)

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    Article

    Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery

    The enhanced extravasation of nanoparticles from tumour blood vessels into the tumour interstitial space has been found to be due to dynamic vents that form transient openings and closings at leaky blood vesse...

    Yu Matsumoto, Joseph W. Nichols, Kazuko Toh, Takahiro Nomoto in Nature Nanotechnology (2016)

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    Chapter

    Nanotechnology for Cancer Treatment: Possibilities and Limitations

    Drug delivery to solid tumors is one of the seminal challenges to develo** more effective cancer therapies. A well-designed drug delivery system can potentially improve the efficacy of a treatment by enhanci...

    Joseph W. Nichols, You Han Bae in Cancer Targeted Drug Delivery (2013)

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    Chapter and Conference Paper

    Secondary instability in variable-density round jets

    Side jet formation in variable-density round jets is investigated by means of direct numerical simulation (DNS) and linear stability analysis. From DNS, it is observed that a light jet with density ratio S0j

    Joseph W. Nichols, Jean-Marc Chomaz, Peter J. Schmid in Advances in Turbulence XI (2007)