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  1. No Access

    Article

    PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection

    Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) characterized by the production ...

    Joseph A. Perry, Lindsey Shallberg, Joseph T. Clark… in Nature Immunology (2022)

  2. No Access

    Article

    Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

    While CD19-directed chimeric antigen receptor (CAR) T cells can induce remission in patients with B cell acute lymphoblastic leukemia (ALL), a large subset relapse with CD19− disease. Like CD19, CD22 is broadly e...

    Nathan Singh, Noelle V. Frey, Boris Engels, David M. Barrett… in Nature Medicine (2021)

  3. No Access

    Article

    Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system

    An important function of the blood–brain barrier is to exclude pathogens from the central nervous system, but some microorganisms benefit from the ability to enter this site. It has been proposed that Toxoplasma ...

    Christoph Konradt, Norikiyo Ueno, David A. Christian… in Nature Microbiology (2016)

  4. Article

    Open Access

    Treatment of leukemia antigen-loss relapses occurring after CD19-targeted immunotherapies by combination of anti-CD123 and anti-CD19 chimeric antigen receptor T cells

    Marco Ruella, David M Barrett, Saad S Kenderian… in Journal for ImmunoTherapy of Cancer (2015)

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  5. No Access

    Article

    Immune response and immunopathology during toxoplasmosis

    Toxoplasma gondii is a protozoan parasite of medical and veterinary significance that is able to infect any warm-blooded vertebrate host. In addition to its importance to public health, several i...

    Christopher D. Dupont, David A. Christian… in Seminars in Immunopathology (2012)

  6. No Access

    Article

    Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells

    T cells in the brains of Toxoplasma-infected mice are shown to move by Lévy-like walks.

    Tajie H. Harris, Edward J. Banigan, David A. Christian, Christoph Konradt… in Nature (2012)

  7. No Access

    Article

    Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding

    Selective binding of multivalent ligands within a mixture of polyvalent amphiphiles provides, in principle, a simple mechanism for driving domain formation in self-assemblies. Divalent cations are shown here t...

    David A. Christian, Aiwei Tian, Wouter G. Ellenbroek, Ilya Levental… in Nature Materials (2009)

  8. No Access

    Article

    Nanopolymeric Therapeutics

    Polymers have been extensively utilized in the design of nanometer-sized delivery vehicles of chemotherapeutics for clinical cancer therapy. Polymeric nanoparticulate delivery vehicles, with chemotherapeutics ...

    Rong Tong, David A. Christian, Li Tang, Horacio Cabral, James R. Baker Jr.… in MRS Bulletin (2009)