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Open AccessMycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine
Antimicrobial peptides (AMPs), ancient scavengers of bacteria, are very poorly induced in macrophages infected by Mycobacterium tuberculosis (M. tuberculosis), but the underlying mechanism remains unknown. Here, ...
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Article
Open AccessAnti-friction gold-based stretchable electronics enabled by interfacial diffusion-induced cohesion
Stretchable electronics that prevalently adopt chemically inert metals as sensing layers and interconnect wires have enabled high-fidelity signal acquisition for on-skin applications. However, the weak interfa...
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Open AccessExploring the mechanism and phytochemicals in Psoraleae Fructus-induced hepatotoxicity based on RNA-seq, in vitro screening and molecular docking
Psoraleae Fructus (PF) is a widely-used herb with diverse pharmacological activities, while its related hepatic injuries have aroused public concerns. In this work, a systematic approach based on RNA sequencin...
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Open AccessAnalysis of factors associated with delayed diagnosis and treatment of testicular torsion in 1005 cases from Chongqing city, China: a cross-sectional study
This study aimed to investigate the clinical and social factors of delayed treatment for testicular torsion (TT) and to explore the risk factors of testicular excision in China. The clinical data of 1005 patie...
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Open AccessInhibition of chitin deacetylases to attenuate plant fungal diseases
Phytopathogenic fungi secrete chitin deacetylase (CDA) to escape the host’s immunological defense during infection. Here, we showed that the deacetylation activity of CDA toward chitin is essential for fungal ...
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Open AccessMechanical metamaterials made of freestanding quasi-BCC nanolattices of gold and copper with ultra-high energy absorption capacity
Nanolattices exhibit attractive mechanical properties such as high strength, high specific strength, and high energy absorption. However, at present, such materials cannot achieve effective fusion of the above...
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Open AccessUnintended consequences of combating desertification in China
Since the early 2000s, China has carried out extensive “grain-for-green” and grazing exclusion practices to combat desertification in the desertification-prone region (DPR). However, the environmental and soci...
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Article
Open AccessThe classical pathway triggers pathogenic complement activation in membranous nephropathy
Membranous nephropathy (MN) is an antibody-mediated autoimmune disease characterized by glomerular immune complexes containing complement components. However, both the initiation pathways and the pathogenic si...
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Open AccessAuthor Correction: BTLA suppress acute rejection via regulating TCR downstream signals and cytokines production in kidney transplantation and prolonged allografts survival
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Open AccessPeople’s perceptions and experience of managing life after recurrent pancreatitis: a qualitative study in eastern China
There is a high rate of recurrent hypertriglyceridemic acute pancreatitis (HTG-RAP) and risk of develo** into chronic pancreatitis among recurrent hypertriglyceridemic acute pancreatitis. The key to avoiding...
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Open AccessQuantitative investigation on the heterogeneity of deformation fields in sandstone pre-existing cracks during damage evolution
The inherently heterogeneous microstructures of rocks lead to heterogeneity of the deformation distribution within the rock volume. In this study, experiments were conducted on red sandstone specimens with fou...
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Open AccessA quantitative study on the impact of working environment on the well-being of teachers in China’s private colleges
Teacher well-being is a prominent issue in policy and public debates. Those teachers working in private schools deserve concern given concerns about their working environment. Focus of this study: to learn abo...
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Open AccessA case of antiferrochirality in a liquid crystal phase of counter-rotating staircases
Helical structures continue to inspire, prompted by examples such as DNA double-helix and alpha-helix in proteins. Most synthetic polymers also crystallize as helices, which relieves steric clashes by twisting...
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Open AccessOxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages
Oxidative stress contributes to the pathogenesis of acute lung injury. Protein S-glutathionylation plays an important role in cellular antioxidant defense. Here we report that the expression of deglutathionyla...
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Open AccessPerformance of different adiposity measures for predicting left ventricular remodeling in Chinese hypertensive youth
There is no consistent conclusion on which adiposity measure is best to predict cardiovascular risk factors in youth. The present study aims to assess the performance of body mass index (BMI), waist circumfere...
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Open AccessEndothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization
SHP2 mediates the activities of multiple receptor tyrosine kinase signaling and its function in endothelial processes has been explored extensively. However, genetic studies on the role of SHP2 in tumor angiog...
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Open AccessMulti-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes
Primary small cell carcinoma of the esophagus (PSCCE) is a lethal neuroendocrine carcinoma. Previous studies proposed a genetic similarity between PSCCE and esophageal squamous cell carcinoma (ESCC) but provid...
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Open AccessAutosomal dominant tubulointerstitial kidney disease genotype and phenotype correlation in a Chinese cohort
Genes of UMOD, HNF1B, MUC1, REN and SEC61A1 were reported to be associated with autosomal dominant tubulointerstitial kidney disease (ADTKD). 48 probands and their family members (N = 27) were enrolled in this ge...
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Open AccessVariation of rhizosphere microbial community in continuous mono-maize seed production
Soil microbe is crucial to a healthy soil, therefore its diversities and abundances under different conditions are still need fully understand.The aims of the study were to characterize the community structure...
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Open AccessEfficient Synchronous Extraction of Nickel, Copper, and Cobalt from Low–Nickel Matte by Sulfation Roasting‒Water Leaching Process
Considering that the low recovery efficiency and the massive loss of valuable metals by the traditional pyrometallurgical process smelting low‒nickel matte. Therefore, this paper focuses on studying the optima...