5 Result(s)
within
E. T. Rietschel
English
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Chapter
Structure and Activity of Endotoxins
Gram-negative bacteria comprise a great number of pathogenic microorganisms causing a variety of diseases in mammals, including man. Many of the clinical symptoms observed following an infection with gram-nega...
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Article
Layered murein revisited: a fundamentally new concept of bacterial cell wall structure, biogenesis and function
The classical concept of the architecture of microbial murein assumes cross-linked glycan chains to be arranged in horizontal layers outside of the plasma membrane. It necessitates elaborate hypotheses to exp...
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Article
Molecular mechanisms of sepsis
Today a great number of problems in the field of bacterial sepsis remain to be solved. Understanding the molecular mechanisms of one of the most important bacterial products in the pathogenesis of sepsis – en...
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Chapter
Bacterial Endotoxin: Chemical Constitution, Biological Recognition, Host Response, and Immunological Detoxification
The discovery of endotoxin dates from the late nineteenth century when Richard Pfeiffer, then working in Berlin, characterized endotoxins as heat-stable and cell-associated molecules (Westphal et al. 1977), thus ...
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Chapter
The Active Principle of Bacterial Lipopolysaccharides (Endotoxins) for Cytokine Induction
Toxic agents in bacterial cultures have been discov ered in the last decades of the nineteenth century. Pfeiffer described endotoxic in addition to exotoxic activities (Pfeiffer 1892), which include fever (Cen...
