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Article
Pentoxyphylline and propentophylline are inhibitors of TNF-α release in monocytes activated by advanced glycation endproducts
Non-enzymatic glycation of proteins with reducing sugars and subsequent transition metal-catalyzed oxidation leads to the formation of protein-bound “advanced glycation endproducts” (AGEs). They accumulate on ...
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Chapter
Structure and Activity of Endotoxins
Gram-negative bacteria comprise a great number of pathogenic microorganisms causing a variety of diseases in mammals, including man. Many of the clinical symptoms observed following an infection with gram-nega...
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Chapter and Conference Paper
Intracellular Protein Modification and Signal Transduction in Response to Lipopolysaccharide
Post-translational covalent modifications are powerful tools to regulate protein functions. Modifications may occur e. g. via acylation, hydroxylation, methylation, thiolation, glycosylation, ADP (adenosine di...
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Chapter
Bacterial Endotoxin: Chemical Constitution, Biological Recognition, Host Response, and Immunological Detoxification
The discovery of endotoxin dates from the late nineteenth century when Richard Pfeiffer, then working in Berlin, characterized endotoxins as heat-stable and cell-associated molecules (Westphal et al. 1977), thus ...
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Article
In-vivo studies on C2 organic acids in the tissues of rats injected with xylitol and glucose
Oxalic, glyoxylic, and glycollic acid were determined in rat liver and kidney after injection with [U-14C]-xylitol or [U-14C]-glucose. Neither glucose nor xylitol led to the formation of oxalic and glyoxylic acid...
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Article
Stoffwechseluntersuchungen unter Einnahme oraler Kontrazeptiva
Verabreichung oraler Kontrazeptiva kann zu Störungen im Kohlenhydrat-Fett-Protein-Vitamin- und Mineralstoffhaushalt führen. Dabei ist nicht so sehr der Typ der Kontrazeptiva sondern die verwendeten Östrogen- u...
