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  1. No Access

    Article

    The biology of endotoxin

    Endotoxin (lipopolysaccharide, LPS) is the major component of the outer leaflet of Gram-negative bacteria and has profound immunostimulatory and inflammatory capacity. The septic shock syndrome caused by endot...

    H. Heine, E. Th. Rietschel, A. J. Ulmer in Molecular Biotechnology (2001)

  2. No Access

    Article

    Molecular mechanisms of sepsis

    Today a great number of problems in the field of bacterial sepsis remain to be solved. Understanding the molecular mechanisms of one of the most important bacterial products in the pathogenesis of sepsis – en...

    A. Woltmann, L. Hamann, A. J. Ulmer, J. Gerdes… in Langenbeck's Archives of Surgery (1998)

  3. No Access

    Chapter

    Bacterial Endotoxin: Chemical Constitution, Biological Recognition, Host Response, and Immunological Detoxification

    The discovery of endotoxin dates from the late nineteenth century when Richard Pfeiffer, then working in Berlin, characterized endotoxins as heat-stable and cell-associated molecules (Westphal et al. 1977), thus ...

    E. T. Rietschel, H. Brade, O. Holst, L. Brade… in Pathology of Septic Shock (1996)

  4. No Access

    Article

    Specific binding of bacillus Calmette-Guérin to urothelial tumor cells in vitro

    Intravesical immunotherapy with bacillus Calmette-Guérin (BCG) against recurrences of superficial bladder cancer and carcinoma in situ is a highly effective regimen in urology. Despite intensive efforts to cla...

    B. Schneider, A. Thanhäuser, D. Jocham, H. Loppnow, E. Vollmer… in World Journal of Urology (1994)

  5. No Access

    Article

    On the mode of action of intravesical bacillus Calmette-Guérin: in vitro characterization of BCG-activated killer cells

    Previously we had shown that, upon activation with viable bacillus Calmette-Guérin (BCG), peripheral blood mononuclear cells (PBMNC) could be rendered cytotoxic against otherwise insensitive natural killer (NK...

    A. Böhle, A. Thanhäuser, A. J. Ulmer, T. Mattern, M. Ernst… in Urological Research (1994)

  6. Article

    Abstract

    Ch. Mache, Ch. Urban, H. Sauer, G. Brandesky, H. Meßner… in Annals of Hematology (1992)

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  7. No Access

    Chapter and Conference Paper

    In Vitro Cellular Cytotoxicity Against Human Bladder Carcinoma Cell Lines

    Clinical trials of intravesical BCG immunotherapy against superficial urothelial bladder carcinoma recurrences have yielded significant results, which seem to be superior to those of intravesical chemotherapy ...

    A. Böhle, A. J. Ulmer, M.-H. Wang, H.-D. Flad in Investigative Urology 4 (1991)

  8. No Access

    Chapter and Conference Paper

    Molecular Aspects of the Chemistry and Biology of Endotoxin

    Endotoxins are integral constituents of the outer membrane of gram-negative bacteria such as the Enterobacteriaceae, Neisseriaceae, and Chlamydiaceae (Lüderitz et al. 1982). They participate in various physiol...

    E. Th. Rietschel, T. Kirikae, W. Feist, H. Loppnow… in Molecular Aspects of Inflammation (1991)

  9. No Access

    Chapter and Conference Paper

    Herabgesetzte T-Zellkolonienbildung bei Patienten mit malignen Tumoren

    Die Reaktion von Lymphozyten in der Suspensionskultur auf mitogene und allogène Zellen ist im allgemeinen bei Patienten mit soliden Tumoren lange Zeit im Verlauf ihrer Erkrankung nicht beeinträchtigt, sondern ...

    M. Betzler, C. Herfarth, H. D. Flad… in Verhandlungen der Deutschen Gesellschaft f… (1980)