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  1. No Access

    Article

    A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling

    MD-2 is an accessory protein of the Toll-like receptor (TLR)-4, necessary for assembling a receptor complex to sense low quantities of lipopolysaccharide in order to subsequently trigger innate immune response...

    L Hamann, O Kumpf, M Müller, A Visintin, J Eckert, P M Schlag… in Genes & Immunity (2004)

  2. No Access

    Chapter

    Structure and Activity of Endotoxins

    Gram-negative bacteria comprise a great number of pathogenic microorganisms causing a variety of diseases in mammals, including man. Many of the clinical symptoms observed following an infection with gram-nega...

    S. Hauschildt, W. Brabetz, A. B. Schromm, L. Hamann, P. Zabel… in Bacterial Protein Toxins (2000)

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    Article

    Molecular mechanisms of sepsis

    Today a great number of problems in the field of bacterial sepsis remain to be solved. Understanding the molecular mechanisms of one of the most important bacterial products in the pathogenesis of sepsis – en...

    A. Woltmann, L. Hamann, A. J. Ulmer, J. Gerdes… in Langenbeck's Archives of Surgery (1998)