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Chapter
Bacterial Endotoxin: Chemical Constitution, Biological Recognition, Host Response, and Immunological Detoxification
The discovery of endotoxin dates from the late nineteenth century when Richard Pfeiffer, then working in Berlin, characterized endotoxins as heat-stable and cell-associated molecules (Westphal et al. 1977), thus ...
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Article
Specific binding of bacillus Calmette-Guérin to urothelial tumor cells in vitro
Intravesical immunotherapy with bacillus Calmette-Guérin (BCG) against recurrences of superficial bladder cancer and carcinoma in situ is a highly effective regimen in urology. Despite intensive efforts to cla...
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Article
On the mode of action of intravesical bacillus Calmette-Guérin: in vitro characterization of BCG-activated killer cells
Previously we had shown that, upon activation with viable bacillus Calmette-Guérin (BCG), peripheral blood mononuclear cells (PBMNC) could be rendered cytotoxic against otherwise insensitive natural killer (NK...
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Chapter
The Active Principle of Bacterial Lipopolysaccharides (Endotoxins) for Cytokine Induction
Toxic agents in bacterial cultures have been discov ered in the last decades of the nineteenth century. Pfeiffer described endotoxic in addition to exotoxic activities (Pfeiffer 1892), which include fever (Cen...
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Article
Abstract
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Chapter and Conference Paper
In Vitro Cellular Cytotoxicity Against Human Bladder Carcinoma Cell Lines
Clinical trials of intravesical BCG immunotherapy against superficial urothelial bladder carcinoma recurrences have yielded significant results, which seem to be superior to those of intravesical chemotherapy ...
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Chapter and Conference Paper
Molecular Aspects of the Chemistry and Biology of Endotoxin
Endotoxins are integral constituents of the outer membrane of gram-negative bacteria such as the Enterobacteriaceae, Neisseriaceae, and Chlamydiaceae (Lüderitz et al. 1982). They participate in various physiol...
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Chapter
Lipid A, the Immunostimulatory Principle of Lipopolysaccharides ?
Lipopolysaccharide (LPS) is an inducer of toxic and immunostimulatory or immunoregulatory responses (2). The lipid A moiety was shown to be the endotoxic principle of LPS (3, 9). Data about immunostimulatory p...
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Article
Book reviews
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Article
Book reviews
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Article
Book reviews
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Chapter
Adjuvant Intermittent Chemoimmunotherapy for Primary Breast Cancer: A Prospective Study with Immunologic Follow-Up
In an interdisciplinary prospective study 50 patients surgically treated for breast cancer were treated with six monthly courses of aggressive adjuvant chemotherapy (adriamycin and cyclophosphamide) and were r...
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Chapter and Conference Paper
Natürliche Killerzell-Aktivität während einer Behandlung mit Fibroblasten-Interferon beim Magencarcinom
Interferon gewinnt in den letzten Jahren zunehmendes klinisches Interesse als neue therapeutische Substanz bei der Behandlung viraler und neoplastischer Erkrankungen. Tierexperimentelle Ergebnisse weisen darau...
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Article
286. Perioperative Überprüfung der Immunreaktion vom verzögerten Typ durch Recall-Antigene bei Carcinom-Patienten
The aim of this study was to test DCH reactions preoperatively in patients with solid malignancies and to find out if there is any correlation to clinical stage. In an incurable tumor stage the number of posit...
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Chapter and Conference Paper
Postoperative individuelle Verlaufskontrollen der natürlichen Killerzell-Aktivität und der CEA-Werte bei Patienten mit gastrointestinalen Carcinomen
Die natürlichen Killerzellen (NK), eine lymphatische Subpopulation, können spontan, d.h. ohne vorherige Sensibilisierung, Targetzellen zerstören; dieser Vorgang wird spontane „Zellvermittelte Cytotoxizität“ ge...
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Article
Buchbesprechungen
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Chapter
Split Chimerism in Three Patients Suffering from Severe Combined Immunodeficiency (SCID)
Three children, suffering from SCID, were lacking a genotypically identical sibling. One of them demonstrated spontaneous graft-versus-host (GvH) reaction due to a maternofetal transfusion. They were transplan...
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Chapter and Conference Paper
Herabgesetzte T-Zellkolonienbildung bei Patienten mit malignen Tumoren
Die Reaktion von Lymphozyten in der Suspensionskultur auf mitogene und allogène Zellen ist im allgemeinen bei Patienten mit soliden Tumoren lange Zeit im Verlauf ihrer Erkrankung nicht beeinträchtigt, sondern ...
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Article
Graft-versus-host reaction after blood transfusion in a patient with cellular immunodeficiency: The role of histocompatibility testing
A patient with an inborn cellular immunodeficiency syndrome developed a graft-versus-host reaction after a transfusion with packed red cells. This diagnosis was confirmed by skin biopsy and finally proved by t...
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Chapter and Conference Paper
Role of an Immunoregulatory Serum Component in Human Mixed Lymphocyte Reaction
Mitogen or MLC responses of mouse spleen cells can be induced in the absence of serum, but the responses obtained are usually much weaker than with the addition of serum and require the presence of either acce...
