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Article
Early-life prefrontal cortex inhibition and early-life stress lead to long-lasting behavioral, transcriptional, and physiological impairments
Early-life stress has been linked to multiple neurodevelopmental and neuropsychiatric deficits. Our previous studies have linked maternal presence/absence from the nest in develo** rat pups to changes in pre...
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Article
Open AccessMap** the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons
In mood disorders, psychomotor and sensory abnormalities are prevalent, disabling, and intertwined with emotional and cognitive symptoms. Corticostriatal neurons in motor and somatosensory cortex are implicate...
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Article
Heightened fear in the absence of the kainate receptor auxiliary subunit NETO2: implications for PTSD
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Article
Open AccessCommon Variants of the Genes Encoding Erythropoietin and Its Receptor Modulate Cognitive Performance in Schizophrenia
Erythropoietin (EPO) improves cognitive performance in clinical studies and rodent experiments. We hypothesized that an intrinsic role of EPO for cognition exists, with particular relevance in situations of co...
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Article
Open AccessExpression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice
Erythropoietin (EPO) and its receptor (EPOR) are expressed in the develo** brain and their transcription is upregulated in adult neurons and glia upon injury or neurodegeneration. We have shown neuroprotecti...
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Article
Open AccessErythropoietin enhances hippocampal long-term potentiation and memory
Erythropoietin (EPO) improves cognition of human subjects in the clinical setting by as yet unknown mechanisms. We developed a mouse model of robust cognitive improvement by EPO to obtain the first clues of ho...
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Article
Open AccessEpisode-Specific Differential Gene Expression of Peripheral Blood Mononuclear Cells in Rapid Cycling Supports Novel Treatment Approaches
Molecular mechanisms underlying bipolar affective disorders are unknown. Difficulties arise from genetic and phenotypic heterogeneity of patients and the lack of animal models. Thus, we focused on only one pat...
