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Article
Open AccessErythropoietin re-wires cognition-associated transcriptional networks
Recombinant human erythropoietin (rhEPO) has potent procognitive effects, likely hematopoiesis-independent, but underlying mechanisms and physiological role of brain-expressed EPO remained obscure. Here, we pr...
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Article
Open AccessFunctional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian brain. In clinical settings, recombinant EPO treatment has revealed a remarkable improvement of cognition, but underl...
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Article
Genetic ablation of VIAAT in glycinergic neurons causes a severe respiratory phenotype and perinatal death
Both glycinergic and GABAergic neurons require the vesicular inhibitory amino acid transporter (VIAAT) for synaptic vesicle filling. Presynaptic GABA concentrations are determined by the GABA-synthesizing enz...
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Article
Open AccessGenetic Markers of a Munc13 Protein Family Member, BAIAP3, Are Gender Specifically Associated with Anxiety and Benzodiazepine Abuse in Mice and Humans
Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together. Unfortunately, treatment of anxiety disorders still includes benzodiazepines, and patients with an exist...
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Article
Analysis of neurotransmitter release mechanisms by photolysis of caged Ca2+ in an autaptic neuron culture system
Neurotransmitter release is triggered by membrane depolarization, Ca2+ influx and Ca2+ sensing by the release machinery, causing synaptic vesicle (SV) fusion with the plasma membrane. Interlinked is a complex mem...
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Article
Open AccessExpression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice
Erythropoietin (EPO) and its receptor (EPOR) are expressed in the develo** brain and their transcription is upregulated in adult neurons and glia upon injury or neurodegeneration. We have shown neuroprotecti...
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Article
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
Munc13 primes synaptic vesicles for exocytosis. Studies now reveal that the central C2B domain of Munc13 contains a structurally unusual Ca2+ binding site that confers specific phospholipid-binding properties to ...
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Article
A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles
Glutamate loading of synaptic vesicles requires moderate Cl− concentrations, but is inhibited by high Cl−. Here, Schenck et al. show that the glutamate transporter VGLUT1 is itself a chloride channel. Although hi...
