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Article
Open AccessActivation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants
The delayed behavioral response to chronic antidepressants depends on dynamic changes in the hippocampus. It was suggested that the antidepressant protein p11 and the chromatin remodeling factor SMARCA3 mediat...
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Article
Open AccessIdentification of Neurensin-2 as a novel modulator of emotional behavior
Among the hallmarks of major depressive disorders (MDD) are molecular, functional, and morphological impairments in the hippocampus. Recent studies suggested a key role for hippocampal GABAergic interneurons b...
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Article
Open AccessSerotonin receptor 4 in the hippocampus modulates mood and anxiety
Serotonin receptor 4 (5-HT4R) plays an important role in regulating mood, anxiety, and cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like effects in preclinical models. How...
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Article
Open AccessEmergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action
The behavioral response to antidepressants is closely associated with physiological changes in the function of neurons in the hippocampal dentate gyrus (DG). Parvalbumin interneurons are a major class of GABAe...
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Article
Open AccessAhnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior
Genetic polymorphisms of the L-type voltage-gated calcium channel (VGCC) are associated with psychiatric disorders including major depressive disorder. Alterations of S100A10 (p11) level are also implicated in...
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Article
Open AccessAerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome
Down syndrome (DS) is caused by the triplication of human chromosome 21 and represents the most frequent genetic cause of intellectual disability. The trisomic Ts65Dn mouse model of DS shows synaptic deficits ...
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Article
TAAR1 Modulates Cortical Glutamate NMDA Receptor Function
Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor expressed in the mammalian brain and known to influence subcortical monoaminergic transmission. Monoamines, such as dopamine, also play...
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Article
Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels
In the central nervous system, most synapses show a fast mode of neurotransmitter release known as synchronous release followed by a phase of asynchronous release, which extends over tens of milliseconds to se...
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Article
Open AccessErythropoietin enhances hippocampal long-term potentiation and memory
Erythropoietin (EPO) improves cognition of human subjects in the clinical setting by as yet unknown mechanisms. We developed a mouse model of robust cognitive improvement by EPO to obtain the first clues of ho...
