11 Result(s)
within
Dennis D. Taub
Immunology
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Article
Open AccessControlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production
Intermittent fasting (IF) improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However, no studies have evaluated the impact of controlled ...
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Article
Open AccessCXCL10 blockade protects mice from cyclophosphamide-induced cystitis
Alterations in serum CXCR3 ligand levels were examined in interstitial cystitis (IC) patients; similar expression patterns in serum as well as CXCR3, CXCR3 ligands, and cytokines expressed by peripheral and lo...
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Article
Open AccessCXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis
The role of Mycobacteria in the etiology of Crohn's disease (CD) has been a contentious subject for many years. Recently, our laboratory showed that spontaneous colitis in IL-10-/- mice is driven in part by antig...
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Article
Open AccessThe Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production
We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-γ and TNF-α expression by activated human T cells ...
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Article
Open AccessDirect and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes
Vitamin A (VA) deficiency induces a type 1 cytokine response and exogenously provided retinoids can induce a type 2 cytokine response both in vitro and in vivo. The precise mechanism(s) involved in this phenotypi...
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Article
Open AccessAge-associated alterations in CXCL1 chemokine expression by murine B cells
The CXCL1 chemokines, macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant (KC), have been shown to play a role in a number of pathophysiological disease states including e...
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Article
Gene Expression Profiling: From Microarrays to Medicine
With the map** of the human genome comes the ability to identify genes of interest in specific diseases and the pathways involved therein. Laboratory technology has evolved in parallel, providing us with the...
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Article
Open AccessQuantitative differences in lipid raft components between murine CD4+ and CD8+ T cells
Lipid rafts have been shown to play a role in T cell maturation, activation as well as in the formation of immunological synapses in CD4+ helper and CD8+ cytotoxic T cells. However, the differential expression of...
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Protocol
Modified Microchemotaxis Assays
Chemotaxis is the process by which leukocytes are directed to sites of inflammation under the influence of a concentration gradient of the soluble chemotactic molecules. Upon encountering a chemotactic molecul...
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Chapter
The Effects of Human Recombinant MIP-1α, MIP-1β, and Rantes on the Chemotaxis and Adhesion of T Cell Subsets
Different members of the chemokine superfamily chemoattract and activate specific leukocyte subsets. For example, IL-8 predominantly chemoattracts neutrophils in vivo, while MCAF is selectively chemotactic for...
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Chapter
The Effect of Morphine and Dago on the Proliferative Response of Murine Splenocytes
There is an increasing body of evidence supporting the existence of a neural-immune network in which endogenous opioids play a role as mediators (1–3). Endogenous opioids have been shown to have a number of im...
