15 Result(s)

Article

Lanreotide Depot to Treat Gastroenteropancreatic Neuroendocrine Tumors in a US Community Oncology Setting: A Prospective, Observational Study

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) can result in symptoms such as diarrhea, flushing, abdominal pain, and fatigue and are often associated with a significant disease burden and poor progno...

Scott Paulson, David Ray, Sharan Aranha, Amy Scales, Yunfei Wang… in Oncology and Therapy (2022)

Article

A qualitative study to understand the experience of somatostatin analog treatments from the perspective of patients with neuroendocrine tumors

Neuroendocrine tumors (NETs) negatively impact patients’ quality of life. Octreotide long-acting release (LAR) and lanreotide depot are somatostatin analogs (SSAs) approved to treat NETs. The study objective w...

Caroline Seo, Erica Horodniceanu, Rachel Shah, Grace Goldstein… in Supportive Care in Cancer (2022)

Article

Patients’ satisfaction with long-acting injectable somatostatin analog therapy for neuroendocrine tumors

Long-acting somatostatin analogs (LA SSAs) are approved and recommended for the treatment of patients with advanced neuroendocrine tumors (NETs). Given the long duration of therapy and differences in administr...

Christina Darden, Mark Price, David Ray… in Journal of Patient-Reported Outcomes (2021)

Article

Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros… in Genome Biology (2021)

Article

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study re...

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros… in Genome Biology (2019)

Article

Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 ind...

Heming Wang, Jacqueline M. Lane, Samuel E. Jones, Hassan S. Dashti… in Nature Communications (2019)

Article

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components B...

**aodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai… in Nature Communications (2019)

Article

Ectopic Cushing’s syndrome secondary to olfactory neuroblastoma

We present the case of a patient with Cushing’s syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent end...

Kenny Yu, Federico Roncaroli, Tara Kearney, David Ewins… in Acta Neurochirurgica (2018)

Article

A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response

The glucocorticoid receptor (GR) is essential for the stress response in mammals. We investigated potential non-transcriptional roles of GR in cellular stress response using fission yeast as a model.We surpris...

Marina Ptushkina, Toryn Poolman, Mudassar Iqbal, Mark Ashe… in Scientific Reports (2017)

Article

Abstracts from the 3rd International Severe Asthma Forum (ISAF)

M. E. Ketelaar, K. Van De Kant, F. N. Dijk… in Clinical and Translational Allergy (2017)

Article

Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells

CD8 lymphocytes play an important role in the pathogenesis of COPD. Corticosteroids and phosphodiesterase 4 (PDE4) inhibitors are anti-inflammatory drugs used for COPD treatment. Little is known of the combine...

Seamus Grundy, Jonathan Plumb, Manminder Kaur, David Ray… in Respiratory Research (2016)

Article

The role of the liver X receptor in chronic obstructive pulmonary disease

There is a need for novel anti-inflammatory therapies to treat COPD. The liver X receptor (LXR) is a nuclear hormone receptor with anti-inflammatory properties.

Andrew Higham, Simon Lea, Jonathan Plumb, Barbara Maschera… in Respiratory Research (2013)

Article

T lymphocyte insensitivity to corticosteroids in chronic obstructive pulmonary disease

There are increased numbers of activated lymphocytes in the lungs of chronic obstructive pulmonary disease (COPD) patients. The clinical benefits of corticosteroids in COPD patients are limited. Our hypothesis...

Manminder Kaur, Lucy JC Smyth, Paul Cadden, Seamus Grundy… in Respiratory Research (2012)

Article

Case series: The McGrath® videolaryngoscope — an initial clinical evaluation

To document tracheal intubation success rates and airway instrumentation times using the newly designed McGrath® videolaryngoscope.

Ben Shippey, David Ray, Dermot McKeown in Canadian Journal of Anesthesia (2007)

Article

Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic widespread pain and its antecedents

In clinic studies, altered hypothalamic-pituitary-adrenal (HPA) axis function has been associated with fibromyalgia, a syndrome characterised by chronic widespread body pain. These results may be explained by ...

John McBeth, Yee H Chiu, Alan J Silman, David Ray… in Arthritis Research & Therapy (2005)