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  1. No Access

    Article

    General analysis of competitive binding in drug–interceptor–DNA systems

    A general model of competitive binding in drug–interceptor–DNA systems has been developed in order to quantify both the interceptor and protector mechanisms. The model involves full parameterization of the bas...

    A. S. Buchelnikov, A. A. Hernandez Santiago… in European Biophysics Journal (2012)

  2. No Access

    Article

    Quantification of the interceptor action of caffeine on the in vitro biological effect of the anti-tumour agent topotecan

    Using published in vitro data on the dependence of the percentage of apoptosis induced by the anti-cancer drug topotecan in a leukaemia cell line on the concentration of added caffeine, and a general model of ...

    M. P. Evstigneev, A. A. Mosunov, V. P. Evstigneev… in European Biophysics Journal (2011)

  3. No Access

    Article

    Complexation of Biologically Active Aromatic Compounds with DNA in the Presence of Theophylline

    1H NMR measurements (500 MHz) have been used to determine the equilibrium hetero-association constants of theophylline (THP) with various biologically active aromatic compounds (daunomyci...

    A. A. Hernandez Santiago, D. D. Andrejuk… in Journal of Biological Physics (2009)

  4. No Access

    Article

    Formation of complexes of antimicrobial agent norfloxacin with antitumor antibiotics of anthracycline series

    The formation of complexes in solutions of the norfloxacin antimicrobial agent (NOR) with daunomycin (DAU) and nogalamycin (NOG), antitumor anthracycline antibiotics, was studied using 1H NMR spectroscopy. Based ...

    M. P. Evstigneev, K. A. Rybakova, D. B. Davies in Russian Journal of Physical Chemistry A (2007)

  5. No Access

    Article

    Complexation of anthracycline drugs with DNA in the presence of caffeine

    The competitive binding of anthracycline antitumour drugs, [daunomycin (DAU), doxorubicin (DOX) or nogalamycin (NOG)], with caffeine (CAF) to a model DNA oligomer has been investigated by 500 MHz 1H NMR spectrosc...

    M. P. Evstigneev, V. V. Khomich, D. B. Davies in European Biophysics Journal (2006)

  6. No Access

    Article

    Complexation of the quinolone antibiotic norfloxacin with DNA

    1H-NMR spectroscopy (500 MHz) was used to study the complexation of the antibacterial agent norfloxacin (NOR) with DNA tetramers 5′-d(TpGpCpA) and 5′-d(CpGpCpG) in aqueous solution. For t...

    M. P. Evstigneev, S. F. Baranovsky, K. A. Rybakova, D. B. Davies in Molecular Biology (2006)

  7. No Access

    Article

    Heteroassociation of antibiotic norfloxacin with aromatic vitamins in aqueous solution

    Heteroassociation of antibacterial antibiotic norfloxacin with aromatic vitamins nicotinamide and flavin mononucleotide in aqueous solution was studied by 1H NMR spectroscopy (500 MHz). Equilibrium constants, ind...

    M. P. Evstigneev, K. A. Rybakova, D. B. Davies in Biophysics (2006)

  8. No Access

    Article

    Self-association of daunomycin antibiotic in various buffer solutions

    The self-association of an antitumor antibiotic, daunomycin (DAU), in various buffer solutions, including water-salt solutions, phosphate buffer, HEPES, and TRIS, was studied by 1D and 2D 1H NMR spectroscopy at 5...

    M. P. Evstigneev, V. V. Khomich, D. B. Davies in Russian Journal of Physical Chemistry (2006)

  9. No Access

    Article

    Interaction between aromatic antibiotics and vitamins: 1H NMR study of heteroassociation of nicotinamide and anthracycline antitumor antibiotics

    The interaction of the anthracycline antitumor antibotics daunomycin and novatrone with the vitamin nicotinamide has been studied by one-and two-dimensional 1H NMR (500 MHz). Due to significant differences betwee...

    A. O. Rozvadovskaya, V. P. Evstigneev, D. B. Davies, M. P. Evstigneev in Biophysics (2006)

  10. No Access

    Article

    A Structural and Thermodynamic Analysis of Novatrone and Flavin Mononucleotide Heteroassociation in Aqueous Solution by 1H NMR Spectroscopy

    A heteroassociation of the antitumor antibiotic novatrone (NOV) and flavin mononucleotide (FMN) in aqueous solution was studied by one- and two-dimentional 1H NMR spectroscopy (500 MHz) to elucidate the molecular...

    A. N. Veselkov, M. P. Evstigneev… in Russian Journal of Bioorganic Chemistry (2005)

  11. No Access

    Article

    Analysis by Means of 1H NMR Spectroscopy of Heteroassociaion in Water Solution of Antitumor Antibiotics Daunomycin and Actinomycin D

    Heteroassociation of aromatic antitumor antibiotics daunomycin (DAU) and actinomycin D (AMD) was investigated using 1D and 2D 1H NMR spectroscopy (at 500 MHz) and molecular mechanics procedure with the goal of es...

    M.P. Evstigneev, A.O. Rozvadovskaya, O.V. Zubchenok… in Russian Journal of Organic Chemistry (2005)

  12. No Access

    Article

    Structural analysis of the complex of phenoxazone antibiotic actinocyl-bis(2-dimethylaminoethyl)amide with deoxytetranucleotide 5′-d(TpGpCpA) by two-dimensional 1H-NMR spectroscopy and molecular mechanics

    The spatial structure of an intercalated complex of the synthetic phenoxazone antibiotic actinocyl-bis-(2-dimethylaminoethyl)amide (ActII) and the self-complementary deoxytetranucleotide 5′-d(TpGpCpA) was stud...

    A. N. Veselkov, L. N. Djimant, K. A. Veselkov, D. B. Davies in Molecular Biology (2005)

  13. No Access

    Article

    Structural and thermodynamic analysis of heteroassociation of daunomycin and flavin mononucleotide molecules in water by 1H NMR spectroscopy

    Heteroassociation of the antitumor antibiotic daunomycin (DAU) with flavin mononucleotide (FMN) has been investigated by one-and two-dimensional 1H NMR spectroscopy (500 MHz) in a water solution to determine the ...

    M. P. Evstigneev, A. O. Rozvadovskaya, A. S. Chubarov… in Journal of Structural Chemistry (2005)

  14. No Access

    Article

    1H NMR Study of Heteroassociation of Ethidium Homodimer and Propidium Iodide in Water

    1D and 2D 1H NMR spectroscopy (500 MHz) was used to study heteroassociation of the bifunctional intercalator ethidium homodimer (EBH) with a phenanthridine dye propidium iodide (PI) in an aqueous salt (0.1 mol/l ...

    A. N. Veselkov, M. P. Evstigneev, S. A. Hernandez… in Journal of Structural Chemistry (2004)

  15. No Access

    Article

    Thermodynamic Analysis of Self-association of Actinocin Bis(2-dimethylaminoethyl)amide in Aqueous Solution by 1H NMR Spectroscopy

    Self-association of a synthetic antibiotic, actinocin bis(2-dimethylaminoethyl)amide (ActII), in aqueous solution was studied by one- and two-dimensional 1H NMR spectroscopy (500 MHz).

    A. N. Veselkov, A. O. Lantushenko, O. V. Rogova… in Russian Journal of Organic Chemistry (2003)

  16. No Access

    Article

    Heteroassociation of Caffeine with the Antibiotic Actinocyl- bis(3-dimethylaminopropylamine) in Aqueous Solution: 1H NMR Analysis

    The heteroassociation of caffeine (CAF) and the synthetic antibiotic actinocyl-bis(3-dimethylaminopropylamine) (ACT) was studied in aqueous solution by one- and two-dimensional 1H NMR spectroscopy at 500 MHz. The...

    A. N. Veselkov, A. O. Lantushenko… in Russian Journal of Bioorganic Chemistry (2002)

  17. No Access

    Article

    NMR Study of Complexation of Aromatic Ligands with Heptadeoxynucleotide 5"-d(GCGAAGC) Forming Stable Hairpin Structure in Aqueous Solution

    Complex formation of hairpin-producing heptadeoxynucleotide 5"-d(GCGAAGC) with aromatic molecules: acridine dye proflavine and anthracycline antibiotic daunomycin was studied by one-dimensional 1H NMR and two-dim...

    A. N. Veselkov, R. J. Eaton, A. V. Semanin, V. I. Pakhomov… in Molecular Biology (2002)

  18. No Access

    Article

    1H NMR Study of Heteroassociation of Daunomycin and Propidium Iodide in Aqueous Solution

    Heteroassociation of an anthracycline antibiotic Daunomycin (DAU) and phenanthridine dye Propidium iodide (PI) in aqueous solution was studied by 1H NMR spectroscopy. The complex PI-DAU is stabilized mainly by di...

    A. N. Veselkov, M. P. Evstigneev, D. A. Veselkov… in Russian Journal of Organic Chemistry (2002)

  19. No Access

    Article

    The Self-Association of Antibiotic Actinocyl-bis(3-dimethylaminopropylamine) in Aqueous Solution: A 1H NMR Analysis

    The self-association of the synthetic antibiotic actinocyl-bis(3-dimethylaminopropylamine) was studied in aqueous solution by one- and two-dimensional 1H NMR spectroscopy at 500 MHz. The two-dimensional homonucle...

    D. A. Veselkov, A. O. Lantushenko, D. B. Davies… in Russian Journal of Bioorganic Chemistry (2002)

  20. No Access

    Article

    Structural and Thermodynamic Analysis of Self-Association of Phenanthridine Dyes in Aqueous Solution by 1H NMR Spectroscopy

    Self-association of phenanthridine dyes (ethidium monoazide EMB and ethidium diazide EDC) in aqueous solution was studied by one- and two-dimensional 1H NMR (500 MHz). 2D-TOCSY and 2D-ROESY experiments were used ...

    A. N. Veselkov, A. O. Lantushenko, D. A. Veselkov… in Journal of Structural Chemistry (2002)

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