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1H NMR Study of Heteroassociation of Daunomycin and Propidium Iodide in Aqueous Solution

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Abstract

Heteroassociation of an anthracycline antibiotic Daunomycin (DAU) and phenanthridine dye Propidium iodide (PI) in aqueous solution was studied by 1H NMR spectroscopy. The complex PI-DAU is stabilized mainly by dispersion van der Waals interactions and hydrogen bond between the 3(8)-amino group of the dye and 9-acetyl group of DAU. This conclusion follows from comparison of parameters of DAU-PI heteroassociation and complex formation of DAU with aromatic dyes, Proflavine and Ethidium bromide, under the same conditions.

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Authors and Affiliations

  1. Sevastopol' State Technical University, Studgorodok, Sevastopol', 99053, Ukraine

    A. N. Veselkov, M. P. Evstigneev & D. A. Veselkov

  2. Birkbeck College, London University, United Kingdom

    D. B. Davies

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  1. A. N. Veselkov
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  2. M. P. Evstigneev
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  3. D. A. Veselkov
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  4. D. B. Davies
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Veselkov, A.N., Evstigneev, M.P., Veselkov, D.A. et al. 1H NMR Study of Heteroassociation of Daunomycin and Propidium Iodide in Aqueous Solution. Russian Journal of Organic Chemistry 38, 1035–1041 (2002). https://doi.org/10.1023/A:1020866032007

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