Abstract
The formation of complexes in solutions of the norfloxacin antimicrobial agent (NOR) with daunomycin (DAU) and nogalamycin (NOG), antitumor anthracycline antibiotics, was studied using 1H NMR spectroscopy. Based on the concentration and temperature dependences of the chemical shifts of the protons of interacting molecules, the equilibrium constants and thermodynamic parameters (enthalpy and entropy) of heteroassociation of the antibiotics were calculated. It was shown that NOR interacts with DAU (NOG) in aqueous solutions forming stacked heterocomplexes with parallel orientation of the molecular chromophores. The conclusion was drawn that such interactions should be taken into account when anthracyclines and quinolones are jointly administered during combined chemotherapy, since they can contribute to the medico-biological synergistic effect of these antibiotics.
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Original Russian Text © M.P. Evstigneev, K.A. Rybakova, D.B. Davies, 2007, published in Zhurnal Fizicheskoi Khimii, 2007, Vol. 81, No. 5, pp. 923–929.
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Evstigneev, M.P., Rybakova, K.A. & Davies, D.B. Formation of complexes of antimicrobial agent norfloxacin with antitumor antibiotics of anthracycline series. Russ. J. Phys. Chem. 81, 802–807 (2007). https://doi.org/10.1134/S0036024407050275
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DOI: https://doi.org/10.1134/S0036024407050275