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Article
Structure Modification and Enhancement of Wear Resistance of Ultra-High-Molecular-Weight Polyethylene by Low-Pressure Helium Plasma Treatment
The surface treatment of ultra-high-molecular-weight polyethylene (UHMWPE) in helium plasma at a pressure of 0.133 mbar has been studied by IR spectroscopy, X-ray photoelectron spectroscopy, and atomic force m...
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Article
Single-walled carbon nanotubes loaded hydroxyapatite–alginate beads with enhanced mechanical properties and sustained drug release ability
Single-walled carbon nanotubes (SWCNTs) containing biomaterial with enhanced mechanical properties for the potential orthopedic application were synthesized and investigated. X-ray diffraction and X-ray fluore...
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Article
Molecular Modeling-Based Energy Analysis of Dimeric Binding of Ligands to the Minor DNA Groove
Molecular-modeling methods have been used to perform energy analysis of dimeric complex formation between lexitropsins and double-stranded DNA. Stabilization of dimeric complexes by hydrophobic and van der Waa...
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Article
Open AccessComparative Analysis of the Antineoplastic Activity of C60 Fullerene with 5-Fluorouracil and Pyrrole Derivative In Vivo
The antitumor activity of pristine C60 fullerene aqueous solution (C60FAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2.5-dione (MI-1) cytostatic dr...
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Article
Physiographic factors of seasonal distribution of linear trends in air temperature on the Azov-Black sea coast
The seasonal distribution of linear trends in air temperature on the coast of the Black and Azov seas in 1936-2010 is analyzed using the quantile regression method. Monthly mean and median values of temperatur...
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Article
PMR Characterization of the Water Structure in Tibetan Milk Mushroom Zooglea: Influence of Medium Hydration and Hydrophobicity
The state of water in Tibetan milk mushroom zooglea with different degrees of hydration (h) was investigated using low-temperature PMR spectroscopy in air and in contact with the hydrophobic media polydimethyl...
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Article
Structural organization of C60 fullerene, doxorubicin, and their complex in physiological solution as promising antitumor agents
Specific features of structural self-organization of C60 fullerene (1 nm size range), antitumor antibiotic doxorubicin (Dox) and their complex in physiological solution (0.9 % NaCl) have been investigated by mean...
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Article
Energy analysis of non-covalent ligand binding to nucleic acids: Present and future
Generalization of current views on energy analysis of complex formation of biologically active compounds with nucleic acids is represented and the outlook for further developments is determined.
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Article
General features of the energetics of complex formation between ligand and nucleic acids
The analysis of the energy contributions of various physical factors to the complex formation between biologically active compounds and nucleic acids in aqueous solution was performed. A comparison of the ener...
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Article
Energy of ligand-RNA complex formation
This work presents an energetic analysis of complex formation of eleven ligands with different structure and charge with RNA aptamers. The most entire set of the components of the total Gibbs energy of complex...
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Article
General analysis of competitive binding in drug–interceptor–DNA systems
A general model of competitive binding in drug–interceptor–DNA systems has been developed in order to quantify both the interceptor and protector mechanisms. The model involves full parameterization of the bas...
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Article
Contribution of enthalpy to the energetics of complex formation of aromatic ligands with DNA
The energy contributions of electrostatic, van der Waals interactions, hydrogen bonds, and interactions of charge transfer type to the enthalpy of complex formation of the double-stand DNA with the antitumor a...
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Article
Quantification of the interceptor action of caffeine on the in vitro biological effect of the anti-tumour agent topotecan
Using published in vitro data on the dependence of the percentage of apoptosis induced by the anti-cancer drug topotecan in a leukaemia cell line on the concentration of added caffeine, and a general model of ...
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Article
Thermodynamic analysis of complex formation of ethidium bromide with DNA in water solutions
A thermodynamic analysis of two types of binding of ethidium bromide with DNA: intercalation and binding to the outer surface of a biopolymer has been performed by spectrophotometry. It has been shown that the...
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Article
Calculation of the thermodynamic potentials of changes in translational, rotational, and vibrational degrees of freedom in the dimerization of aromatic molecules
The work presents a method for calculating the thermodynamic potentials (free Gibbs energy, enthalpy, and entropy) and an analysis of the contributions of changes in translational, rotational, and vibrational ...
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Article
Contribution of changes in translational, rotational, and vibrational degrees of freedom to the energy of complex formation of aromatic ligands with DNA
A method for calculation and analysis of the contribution of changes in translational, rotational, and vibrational degrees of freedom to the energy of complex formation of aromatic compounds with DNA duplex ha...
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Article
Complexation of Biologically Active Aromatic Compounds with DNA in the Presence of Theophylline
1H NMR measurements (500 MHz) have been used to determine the equilibrium hetero-association constants of theophylline (THP) with various biologically active aromatic compounds (daunomyci...
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Article
Interaction of ethidium bromide and caffeine with DNA in aqueous solution
Two component (ethidium bromide–caffeine, ethidium bromide–DNA) and three component (ethidium bromide–caffeine–DNA) systems in aqueous saline (0.01 M NaCl) phosphate buffer solutions (pH 6.86, T = 298 K) are stud...
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Article
Complexation of heterocyclic ligands with DNA in aqueous solution
We have used spectrophotometry to study self-association and complexation with DNA by organic heterocyclic compounds in the acridine and phenothiazine series: proflavin, thionine, and methylene blue. Based on ...
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Article
A “microscopic” model of complexation between intercalators and DNA: Analysis of NMR spectroscopy data
A model is proposed for intercalation of ligands into an arbitrary oligonucleotide sequence, which makes allowance in explicit form for the microscopic constants and parameters of cooperative binding to partic...
