27 Result(s)

Article

Retrievable IVC square stent filter: Experimental study

Purpose: In vitro and in vivo evaluation of a new retrievable, home-made, inferior vena cava (IVC) Square stent filter (SSF) with two trap** levels.

Dusan Pavcnik, Barry T. Uchida… in CardioVascular and Interventional Radiology (1999)

Article

Endoluminal Treatment of Ruptured Abdominal Aortic Aneurysm with Small Intestinal Submucosa Sandwich Endografts: A Pilot Study in Sheep

To evaluate efficacy of small intestinal submucosa (SIS) Sandwich endografts for the treatment of acute rupture of abdominal aortic aneurysms (AAA) and to explore the short-term reaction of the aorta to this m...

Katsuyuki Yamada, Dusan Pavcnik M.D., Ph.D.… in CardioVascular and Interventional Radiology (2001)

Article

Response to imatinib mesylate of a gastrointestinal stromal tumor with very low expression of KIT

More than 90% of gastrointestinal stromal tumors (GISTs) express the receptor tyrosine kinase KIT, and activating mutations of the KIT gene are detectable in the vast majority of these tumors. Imatinib mesylat...

Sebastian Bauer, Christopher L. Corless… in Cancer Chemotherapy and Pharmacology (2003)

Article

c-CBL is not required for leukemia induction by Bcr-Abl in mice

Bcr-Abl tyrosine kinase activity is essential for the pathogenesis of chronic myeloid leukemia (CML). A number of Bcr-Abl substrates have been identified, but it is not clear which of these substrates are require...

Daniela M Dinulescu, Lisa J Wood, Lei Shen, Marc Loriaux, Christopher L Corless… in Oncogene (2003)

Chapter

Targeting mutant kinases in Gastrointestinal Stromal Tumors: A paradigm for molecular therapy of other sarcomas

Michael C. Heinrich MD… in Targeting Treatment of Soft Tissue Sarcomas (2004)

Article

Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles

Most GISTs require oncogenic activation of the KIT or PDGFRA receptor tyrosine kinase proteins, and the genomic mechanisms of oncogene activation are heterogeneous. Notably, the kinase mutation type correlates wi...

Subbaya Subramanian, Robert B West, Christopher L Corless, Wenbin Ou… in Oncogene (2004)

Article

Experimental Percutaneous Extrahepatic Portacaval Shunt Creation by Transjugular Approach in Swine

The purpose of the study was to evaluate the feasibility of the creation of a percutaneous extrahepatic portacaval shunt (PEPS) in swine by a transjugular approach and to find a suitable stent-graft to use in ...

Chang Kyu Seong, Dusan Pavcnik… in CardioVascular and Interventional Radiology (2005)

Article

Effects of Blood Flow and/or Ventilation Restriction on Radiofrequency Coagulation Size in the Lung: An Experimental Study in Swine

The purpose of this study was to investigate how the restriction of blood flow and/or ventilation affects the radiofrequency (RF) ablation coagulation size in lung parenchyma. Thirty-one RF ablations were done...

Hiroshi Anai, Barry T. Uchida, Dusan Pavcnik… in CardioVascular and Interventional Radiology (2006)

Article

Does tumor mutational status correlate with clinical response to imatinib?

Michael C Heinrich, Christopher L Corless in Nature Clinical Practice Oncology (2006)

Article

Percutaneous Vein Occlusion with Small Intestinal Submucosa: An Experimental Pilot Study in Swine and Sheep

The objective of this study was to investigate the feasibility, outcomes, and amount of small intestinal submucosa (SIS) material needed for embolization of jugular vein (JV) in a swine and sheep model. Our hy...

Man Deuk Kim, Hanno Hoppe, Dusan Pavcnik… in CardioVascular and Interventional Radiology (2007)

Article

Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma

Mutationally activated protein kinases are appealing therapeutic targets in breast carcinoma. Mutations in phosphatidylinositol-3-kinase (PI3KCA) have been described in 8–40% of invasive breast carcinomas, and AK...

Jennifer Dunlap, Claudia Le, Arielle Shukla… in Breast Cancer Research and Treatment (2010)

Article

Absence of BRAF, NRAS, KRAS, HRAS Mutations, and RET/PTC Gene Rearrangements Distinguishes Dominant Nodules in Hashimoto Thyroiditis from Papillary Thyroid Carcinomas

Dominant nodules within Hashimoto thyroiditis (HT) may present with unique morphological features that overlap with but are not diagnostic of papillary thyroid carcinoma (PTC). Activating BRAF point mutations, RA...

Peter M. Sadow, Michael C. Heinrich, Christopher L. Corless… in Endocrine Pathology (2010)

Article

Oncogenes in context

In certain types of gastrointestinal cell, mutations in the protein KIT give rise to gastrointestinal stromal tumours. Why are other cell types that express KIT not affected? The answer lies with a second prot...

Michael C. Heinrich, Christopher L . Corless in Nature (2010)

Chapter

Practical Gastrointestinal Oncology Correlative Science

Gastrointestinal (GI) cancers, like other human malignancies, are characterized by the accumulation of a variety of genetic alterations, including mutations that lead to inactivation of tumor suppressor genes ...

Kay Washington, Christopher L. Corless in Gastrointestinal Oncology (2011)

Article

Novel Biomarker Candidates to Predict Hepatic Fibrosis in Hepatitis C Identified by Serum Proteomics

Liver biopsy remains the gold standard to assess hepatic fibrosis. It is desirable to predict hepatic fibrosis without the need for invasive liver biopsy. Proteomic techniques allow unbiased assessment of prot...

Libang Yang, Kyle D. Rudser, LeeAnn Higgins… in Digestive Diseases and Sciences (2011)

Article

Gastrointestinal stromal tumours: origin and molecular oncology