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    Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma

    Mutationally activated protein kinases are appealing therapeutic targets in breast carcinoma. Mutations in phosphatidylinositol-3-kinase (PI3KCA) have been described in 8–40% of invasive breast carcinomas, and AK...

    Jennifer Dunlap, Claudia Le, Arielle Shukla… in Breast Cancer Research and Treatment (2010)