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Oncogenes in context

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In certain types of gastrointestinal cell, mutations in the protein KIT give rise to gastrointestinal stromal tumours. Why are other cell types that express KIT not affected? The answer lies with a second protein. See Letter p.849

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Figure 1: Gastrointestinal stromal tumour at a cellular level.

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Authors and Affiliations

  1. Michael C. Heinrich is in the Department of Medicine the Portland VA Medical Center and OHSU Knight Cancer Institute, Portland, Oregon 97239-3098, USA. heinrich@ohsu.edu,

    Michael C. Heinrich

  2. Christopher L. Corless is in the Department of Pathology, the Portland VA Medical Center and OHSU Knight Cancer Institute, Portland, Oregon 97239-3098, USA.,

    Christopher L . Corless

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  1. Michael C. Heinrich
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  2. Christopher L . Corless
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Competing interests

* M.C.H.: Research funding from Novartis/Consultant and equity interest in MolecularMD. * C.L.C.: Novartis: consulting fees, honoraria, research contract/Pfizer: consulting fees, honoraria/Asuragen: consulting fee/MolecularMD: consulting fees, research contract/Synta: research contract/SuperGen: research contract

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Heinrich, M., Corless, C. Oncogenes in context. Nature 467, 796–797 (2010). https://doi.org/10.1038/467796a

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