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  1. Article

    Open Access

    Functional and genetic screening of acute myeloid leukemia associated with mediastinal germ cell tumor identifies MEK inhibitor as an active clinical agent

    Hematologic malignancies arising in the setting of established germ cell tumors have been previously described and have a dismal prognosis. Identification of targetable mutations and pathway dysregulation thro...

    Jessica T. Leonard, Philipp W. Raess, Jennifer Dunlap… in Journal of Hematology & Oncology (2016)

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  2. No Access

    Article

    A germline-competent embryonic stem cell line from NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ (NSG) mice

    The NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ mouse strain, commonly known as NSG (for NOD SCID Gam...

    Carlisle P. Landel, Jennifer Dunlap, John B. Patton, Tim Manser in Transgenic Research (2013)

  3. No Access

    Article

    Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma

    Mutationally activated protein kinases are appealing therapeutic targets in breast carcinoma. Mutations in phosphatidylinositol-3-kinase (PI3KCA) have been described in 8–40% of invasive breast carcinomas, and AK...

    Jennifer Dunlap, Claudia Le, Arielle Shukla… in Breast Cancer Research and Treatment (2010)