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Article
Open AccessCarboxyhemoglobin predicts oxygenator performance and imminent oxygenator change in extracorporeal membrane oxygenation
The continuous exposure of blood to a non-biological surface during extracorporeal membrane oxygenation (ECMO) may lead to progressive thrombus formation in the oxygenator, hemolysis and consequently impaired ...
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Article
Open AccessTreatment strategies in MDA5-positive clinically amyopathic dermatomyositis: a single-center retrospective analysis
Melanoma differentiation-associated protein 5 (MDA5) antibody positive amyopathic dermatomyositis (DM) is a rare inflammatory disease. So far, there is no official treatment guideline in MDA5 amyopathic dermat...
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Article
Open AccessCurrent clinical practice in using adjunctive extracorporeal blood purification in sepsis and septic shock: results from the ESICM “EXPLORATION” survey
Despite a lack of clear evidence extracorporeal blood purification (EBP) is increasingly used as an adjunctive treatment in septic shock based on its biological plausibility. However, current state of praxis a...
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Article
Open AccessFever or hypothermia following ECMO decannulation: the association of body temperature with survival
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Article
D-dimer trends in ECMO patients: don’t shoot the messenger
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Article
Open AccessReduced anticoagulation strategy is associated with a lower incidence of intracerebral hemorrhage in COVID-19 patients on extracorporeal membrane oxygenation
Optimal anticoagulation strategies for COVID-19 patients with the acute respiratory distress syndrome (ARDS) on venovenous extracorporeal membrane oxygenation (VV ECMO) remain uncertain. A higher incidence of ...
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Article
Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, characterized by asthma, eosinophilia and granulomatous or vasculitic involveme...
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Article
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19
Anorexia and fasting are host adaptations to acute infection, and induce a metabolic switch towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate (BHB)1–6. However, whether ketogene...
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Article
Where is the imperceptible difference?
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Article
Open AccessClinical and biochemical endpoints and predictors of response to plasma exchange in septic shock: results from a randomized controlled trial
Recently, a randomized controlled trial (RCT) demonstrated rapid but individually variable hemodynamic improvement with therapeutic plasma exchange (TPE) in patients with septic shock. Prediction of clinical e...
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Article
It takes two to bleed: anticoagulation intensity and the host’s vascular susceptibility
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Open AccessPredictors of response to intra-arterial vasodilatory therapy of non-occlusive mesenteric ischemia in patients with severe shock: results from a prospective observational study
Non-occlusive mesenteric ischemia (NOMI) is a life-threatening condition occurring in patients with shock and is characterized by vasoconstriction of the mesenteric arteries leading to intestinal ischemia and ...
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Article
Open AccessTetracycline ameliorates silica-induced pulmonary inflammation and fibrosis via inhibition of caspase-1
Inhalation of dust containing silica particles is associated with severe pulmonary inflammation and lung injury leading to chronic silicosis including fibrotic remodeling of the lung. Silicosis represents a ma...
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Article
Open AccessEffects of therapeutic plasma exchange on the endothelial glycocalyx in septic shock
Disruption of the endothelial glycocalyx (eGC) is observed in septic patients and its injury is associated with multiple-organ failure and inferior outcomes. Besides this biomarker function, increased blood co...
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Article
Open AccessRole of endothelial microRNA 155 on capillary leakage in systemic inflammation
Capillary leakage is a key contributor to the pathological host response to infections. The underlying mechanisms remain incompletely understood, and the role of microRNAs (MIR) has not been investigated in de...
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Article
Open AccessComparison of anticoagulation strategies for veno-venous ECMO support in acute respiratory failure
Extracorporeal membrane oxygenation (ECMO) support in acute respiratory failure may be lifesaving, but bleeding and thromboembolic complications are common. The optimal anticoagulation strategy balancing these...
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Article
Open AccessEffect of therapeutic plasma exchange on endothelial activation and coagulation-related parameters in septic shock
A dysbalanced coagulation system is part of the pathological host response to infection in sepsis. Activation of pro-coagulant pathways and attenuation of anti-coagulant activity ultimately lead to microvascul...
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Article
Open Access“Better be awake”—a role for awake extracorporeal membrane oxygenation in acute respiratory distress syndrome due to Pneumocystis pneumonia
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Article
Open AccessAnti-IL-5 therapy in patients with severe eosinophilic asthma – clinical efficacy and possible criteria for treatment response
Interleukin-5 (IL-5) antibodies represent a promising therapeutic option for patients with severe eosinophilic asthma. To date, no official treatment response criteria exist. In this study, simple criteria for...
