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Open AccessMetabolic disturbances potentially attributable to clogging during continuous renal replacement therapy
Clogging is characterized by a progressive impairment of transmembrane patency in renal replacement devices and occurs due to obstruction of pores by unknown molecules. If citrate-based anti-coagulation is use...
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D-dimer trends in ECMO patients: don’t shoot the messenger
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Open AccessEye-tracking during newborn intubations
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Open AccessReduced anticoagulation strategy is associated with a lower incidence of intracerebral hemorrhage in COVID-19 patients on extracorporeal membrane oxygenation
Optimal anticoagulation strategies for COVID-19 patients with the acute respiratory distress syndrome (ARDS) on venovenous extracorporeal membrane oxygenation (VV ECMO) remain uncertain. A higher incidence of ...
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Open AccessFrom Angiopoietin-2 to basic chemistry: differential effects of statins on endothelial homeostasis in ARDS
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Open AccessDevelopment and validation of a prognostic model for the early identification of COVID-19 patients at risk of develo** common long COVID symptoms
The coronavirus disease 2019 (COVID-19) pandemic demands reliable prognostic models for estimating the risk of long COVID. We developed and validated a prediction model to estimate the probability of known com...
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Open AccessMicrocirculatory alterations in critically ill COVID-19 patients analyzed using artificial intelligence
The sublingual microcirculation presumably exhibits disease-specific changes in function and morphology. Algorithm-based quantification of functional microcirculatory hemodynamic variables in handheld vital mi...
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The challenge of pharmacological thromboprophylaxis in ICU patients: anti-FXa activity does not constitute the simple solution. Author's reply
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Challenging management dogma where evidence is non-existent, weak or outdated
Medical practice is dogged by dogma. A conclusive evidence base is lacking for many aspects of patient management. Clinicians, therefore, rely upon engrained treatment strategies as the dogma seems to work, or...
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Open AccessThe importance of intravenous immunoglobulin treatment in critically ill patients with necrotizing soft tissue infection: a retrospective cohort study
Necrotizing soft-tissue infections are infections with high mortality. The use of immunoglobulins within a combination therapy including broad-spectrum antibiotics has been debated. We assessed potential benef...
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Open AccessUse of eye tracking in analyzing distribution of visual attention among critical care nurses in daily professional life: an observational study
Patient safety is a priority in healthcare, yet it is unclear how sources of errors should best be analyzed. Eye tracking is a tool used to monitor gaze patterns in medicine. The aim of this study was to analy...
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Open AccessCholesterol and its association with muscle weakness in critical illness
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Open AccessBacterial but no SARS-CoV-2 contamination after terminal disinfection of tertiary care intensive care units treating COVID-19 patients
In intensive care units (ICUs) treating patients with Coronavirus disease 2019 (COVID-19) invasive ventilation poses a high risk for aerosol and droplet formation. Surface contamination of severe acute respira...