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Article
Open AccessMonocytes prevent apoptosis of iPSCs and promote differentiation of kidney organoids
Induced pluripotent stem cells (iPSCs)-derived kidney organoids are a promising model for studying disease mechanisms and renal development. Despite several protocols having been developed, further improvement...
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Article
Open AccessAuthor Correction: Calcium dobesilate reduces SARS-CoV-2 entry into endothelial cells by inhibiting virus binding to heparan sulfate
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Article
Open AccessCalcium dobesilate reduces SARS-CoV-2 entry into endothelial cells by inhibiting virus binding to heparan sulfate
Recent reports demonstrate that SARS-CoV-2 utilizes cell surface heparan sulfate as an attachment factor to facilitate the initial interaction with host cells. Heparan sulfate interacts with the receptor bindi...
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Article
Open AccessEffects of therapeutic plasma exchange on the endothelial glycocalyx in septic shock
Disruption of the endothelial glycocalyx (eGC) is observed in septic patients and its injury is associated with multiple-organ failure and inferior outcomes. Besides this biomarker function, increased blood co...
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Article
Open AccessAuthor Correction: Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling
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Article
Open AccessProof-of-Concept Study of Drug Brain Permeability Between in Vivo Human Brain and an in Vitro iPSCs-Human Blood-Brain Barrier Model
The development of effective central nervous system (CNS) drugs has been hampered by the lack of robust strategies to mimic the blood-brain barrier (BBB) and cerebrovascular impairments in vitro. Recent technolog...
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Article
Open AccessHeparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling
The endothelial glycocalyx and its regulated shedding are important to vascular health. Endo-β-D-glucuronidase heparanase-1 (HPSE1) is the only enzyme that can shed heparan sulfate. However, the mechanisms are...
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Article
oxLDL inhibits differentiation of mesenchymal stem cells into osteoblasts via the CD36 mediated suppression of Wnt signaling pathway
Bone abnormalities as a consequence of osteoblast deregulation are associated with several diseases such as diabetes and chronic kidney disease. Important role for oxidized low density lipoproteins (oxLDL) in ...
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Article
Open AccessoxLDL inhibits differentiation and functional activity of osteoclasts via scavenger receptor-A mediated autophagy and cathepsin K secretion
Resorptive activity of osteoclasts is important for maintaining bone homeostasis. Endogenous compounds such as oxidized low density lipoprotein (oxLDL) have been shown to disturb this activity. While some stud...
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Article
Open AccessCHK1 and RAD51 activation after DNA damage is regulated via urokinase receptor/TLR4 signaling
Mechanisms of DNA damage and repair signaling are not completely understood that hinder the efficiency of cancer therapy. Urokinase-type plasminogen activator receptor (PLAUR) is highly expressed in most solid...
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Vascular Aging: Revealing the Role and Clinical Perspectives of the Urokinase System
Cardiovascular diseases (CVD) are the most common cause of death among the elderly population in Western countries. Despite progress in managing some of the established risk factors like hypertension and hyper...
