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Article

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Anorexia and fasting are host adaptations to acute infection, and induce a metabolic switch towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate (BHB)^1–6. However, whether ketogene...

Fotios Karagiannis, Konrad Peukert, Laura Surace, Marcel Michla, Fabian Nikolka… in Nature (2022)