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Article
Open AccessSMYD3: a new regulator of adipocyte precursor proliferation at the early steps of differentiation
In obesity, adipose tissue undergoes a remodeling process characterized by increased adipocyte size (hypertrophia) and number (hyperplasia). The ability to tip the balance toward the hyperplastic growth, with ...
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Article
Open AccessA nontuberculous mycobacterium could solve the mystery of the lady from the Franciscan church in Basel, Switzerland
In 1975, the mummified body of a female has been found in the Franciscan church in Basel, Switzerland. Molecular and genealogic analyses unveiled her identity as Anna Catharina Bischoff (ACB), a member of the ...
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Article
Open AccessRandomly controlled drivers using minimally invasive sampling: assessment of drug prevalence in Western Switzerland over two time periods
According to the World Health Organization, road traffic injuries lead to 1.3 million deaths each year and represent the leading cause of death for young adults under 30 years old. The use of psychoactive subs...
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Article
Open AccessDBnorm as an R package for the comparison and selection of appropriate statistical methods for batch effect correction in metabolomic studies
As a powerful phenoty** technology, metabolomics provides new opportunities in biomarker discovery through metabolome-wide association studies (MWAS) and the identification of metabolites having a regulatory...
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Article
Open AccessDetecting early myocardial ischemia in rat heart by MALDI imaging mass spectrometry
Diagnostics of myocardial infarction in human post-mortem hearts can be achieved only if ischemia persisted for at least 6–12 h when certain morphological changes appear in myocardium. The initial 4 h of ische...
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Article
Oleic Acid (OA), A Potential Dual Contrast Agent for Postmortem MR Angiography (PMMRA): A Pilot Study
Choosing proper perfusates as contrast agents is an important aspect for postmortem magnetic resonance angiography (PMMRA). However, in this emerging field, the number of suitable kinds of liquid is still very...
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Article
Multiplex quantitative imaging of human myocardial infarction by mass spectrometry-immunohistochemistry
Simultaneous assessment of a panel of protein markers is becoming essential in order to enhance biomarker research and improve diagnostics. Specifically, postmortem diagnostics of early myocardial ischemia in ...
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Article
Open AccessA preclinical model for identifying rats at risk of alcohol use disorder
Alcohol use is one of the world’s leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individual...
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Article
Imaging mass spectrometry of elements in forensic cases by LA-ICP-MS
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was performed to map elements in thin formalin-fixed paraffin-embedded tissue sections of two forensic cases with firearm and electrocuti...
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Omics in Forensic Toxicology a Bridge Towards Forensic Medicine
Cutting-edge omic strategies are bringing new opportunities to many fields of investigation from the biomedical to the biomedicolegal. Comprehension of molecular mechanisms associated with pathologies such as ...
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Article
Open AccessDrug va** applied to cannabis: Is “Cannava**” a therapeutic alternative to marijuana?
Therapeutic cannabis administration is increasingly used in Western countries due to its positive role in several pathologies. Dronabinol or tetrahydrocannabinol (THC) pills, ethanolic cannabis tinctures, orom...
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Article
Postmortem serum protein growth arrest-specific 6 levels in sepsis-related deaths
Growth arrest-specific 6 (Gas6) is widely expressed in leukocytes, platelets, endothelial cells, and monocytes. It regulates various processes including granulocyte adhesion to the endothelium, cell migration,...
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Article
Dual-energy CT behavior of heroin, cocaine, and typical adulterants
To investigate the dual-energy CT behavior of cocaine and heroin and of typical adulterants, and to evaluate the elemental composition of pure cocaine and heroin compared with cocaine and heroin in bodypacks.
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Article
Ruptured pseudo-aneurysm of a femoral artery in a drug abuser revealed by post-mortem CT angiography
A 35-year-old drug addict was found dead in a public toilet with a ruptured groin, which was later diagnosed to be a leaking pseudo-aneurysm. Investigation at the scene revealed impressive external hemorrhage ...
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Article
Diagnostic value of lipopolysaccharide-binding protein and procalcitonin for sepsis diagnosis in forensic pathology
The aims of this study were twofold. The first was to investigate the diagnostic performance of two biochemical markers, procalcitonin (PCT) and lipopolysaccharide-binding protein (LBP), considering each indiv...
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Article
Is the formula of Traub still up to date in antemortem blood glucose level estimation?
According to the hypothesis of Traub, also known as the ‘formula of Traub’, postmortem values of glucose and lactate found in the cerebrospinal fluid or vitreous humor are considered indicators of antemortem b...
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Article
Diagnostic performance of ethyl glucuronide in hair for the investigation of alcohol drinking behavior: a comparison with traditional biomarkers
Ethyl glucuronide (EtG) in hair has emerged as a useful biomarker for detecting alcohol abuse and monitoring abstinence. However, there is a need to establish a reliable cutoff value for the detection of chron...
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Article
Open AccessSensitivity and specificity of NT-proBNP to detect heart failure at post mortem examination
NT-proBNP, a marker of cardiac failure, has been shown to be stable in post mortem samples. The aim of this study was to assess the accuracy of NT-proBNP to detect heart failure in the forensic setting. One hu...
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Article
Evaluation of postmortem measurement of NT-proBNP as a marker for cardiac function
Clinical biomarkers of cardiac function could also be monitored postmortem. Among the natriuretic peptides, the aminoterminal portion of pro-brain natriuretic peptide (NT-proBNP) appears to be a more reliable ...
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Article
Codeine accumulation and elimination in larvae, pupae, and imago of the blowfly Lucilia sericata and effects on its development
The aim of this study was to evaluate the reliability of insect larvae as samples for toxicological investigations. For this purpose, larvae of Lucilia sericata were reared on samples of minced pig liver treated ...
