Page
%P
34 Result(s)
within
Anthony S. Fauci
Immunology
-
Article
Activation of human B lymphocytes
The characteristics of human B lymphocyte triggering, differentiation, and regulation are described using the polyclonally induced anti-sheep red blood cell hemolytic plaque-forming cell assay system. Technica...
-
Article
Regulation of human B-cell activation, proliferation, and differentiation by soluble factors
This review describes a series of studies performed in our laboratory which have focused on the activation and subsequent proliferation and differentiation of human B lymphocytes. Utilizing polyclonal signals ...
-
Chapter
Human B-Cell Growth and Differentiation Factors Secreted by T-Cell Hybridomas
Application of the technique of cell hybridization (Köhler and Milstein, 1975) to human and murine T lymphocytes has been an area of recent intense interest and investigation. T-cell hybridomas have been devel...
-
Chapter
Exogenous IL-2 Independent Antigen-Specific Human T Cells: Antigen-Specific Induction of Polyclonal B Cell Factors
The development of antigen-specific T lymphocyte lines and clones has greatly facilitated the investigation of the mechanisms by which T cells recognize foreign antigens and subsequently elaborate immuoregulat...
-
Chapter
The Human B Cell Cycle: Activation, Proliferation, and Differentiation
The full expression of a competent immune response, either cell mediated or humoral, requires the precise cooperation of a number of cell types which communicate either by cell-to-cell contact or by soluble im...
-
Chapter
Vasculitis
Vasculitis refers to the inflammation of and resultant damage to blood vessels, leading to ischemia of distal tissues (Fauci et al., 1978a; Cupps and Fauci, 1981). It is this ischemia with changes in distal tissu...
-
Chapter
Current Studies Examining Regulation of the Human B Cell Cycle
The study of human B cell physiology involves the evaluation of a wide array of functions performed by B lymphocytes including antigen presentation (1), maintenance of memory for antigen (2), lymphokine secret...
-
Article
Host defense againstMycobacterium-avium complex
Mycobacterium-avium complex (MAC) is an intracellular pathogen and the most common cause of widely disseminated bacterial infection in patients with the acquired immunodeficiency syndrome (AIDS). MAC is infreque...
-
Chapter
Alternative Cytokines in the Immunoregulation of the Human B Cell Cycle
A variety of soluble factors have been described which regulate the growth and differentiation of human B lymphocytes in vitro. Several of these factors were orginally recognized by their activity in assays of...
-
Article
A phase I trial of recombinant human interferon-γ in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome (AIDS)
A Phase I study of recombinant interferon-gamma (rIFN-γ) was conducted to determine the toxicity and pharmacokinetics of this lymphokine in acquired immunodeficiency syndrome (AIDS) patients with Kaposi's sarc...
-
Article
Immunology of aids: Approaches to understanding the immunopathogenesis of HIV infection
Infection with human immunodeficiency virus (HIV) causes an extensive array of immunologic abnormalities which ultimately lead to severe immunosuppression, opportunistic disease, and death. Many of the immunol...
-
Chapter
Limited Prognostic Value of Changes in Antineutrophil Cytoplasmic Antibody Titers in Patients with Wegener’s Granulomatosis
One hundred and six patients with Wegener’s granulomatosis (WG) were studied for the presence of antineutrophil cytoplasmic antibodies (ANCA). In 53 patients serial ANCA determinations were obtained. C-ANCA po...
-
Chapter
Cytokine Cascades in HIV Infection
Since the recognition of human immunodeficiency virus type 1 (HIV-1) as the causative agent of the acquired immunodeficiency syndrome (AIDS), the search to unravel the viral and cellular factors controlling it...
-
Article
Interleukin-2 and human immunodeficiency virus infection: Pathogenic mechanisms and potential for immunologic enhancement
A hallmark of human immunodeficiency virus (HIV) infection is the progressive loss of CD4+ T lymphocytes; however, qualitative defects in immune responses occur prior to the precipitous drop CD4+ T cell number...
-
Book
-
Chapter
Virologic and immunologic events in primary HIV infection
It is thought that a significant percentage (50-70%) of human immunodeficiency virus (HIV)-infected individuals experience a clinical syndrome of variable severity during primary infection. The symptoms are no...
-
Chapter
Introduction: Recent advances in the pathogenesis of human immunodeficiency virus infection
During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard ...
-
Chapter
Dendritic Cells Express and Use Multiple HIV Coreceptors
Dendritic cells (DC) are the first immunocompetent cells to encounter antigen at areas of inflammation in mucous membranes1, which are the major sites where the initiation of HIV infection occurs. HIV enters a mu...
-
Chapter
Studies on lymphoid tissue from HIV-infected individuals: implications for the design of therapeutic strategies
Lymphoid tissue is a major reservoir of human immunodeficiency virus (HIV) infection in vivo. In addition, the lymphoid microenvironment provides a replicative advantage to the virus in that it provides a mili...
-
Article
Virologic and immunologic events in primary HIV infection
