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Article
Cyanobacterial blooms, iron, and environmental pollutants
Iron determines the abundance and diversity of life and controls primary production in numerous aqueous environments. Over the past decades, the availability of this metal in natural waters has decreased. Iron...
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Article
Open AccessMonitoring redox stress in human airway epithelial cells exposed to woodsmoke at an air–liquid interface
Wildland fires contribute significantly to the ambient air pollution burden worldwide, causing a range of adverse health effects in exposed populations. The toxicity of woodsmoke, a complex mixture of gases, v...
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Article
Open AccessMucus increases cell iron uptake to impact the release of pro-inflammatory mediators after particle exposure
We tested the hypothesis that (1) mucus production can be included in the cell response to iron deficiency; (2) mucus binds iron and increases cell metal uptake; and subsequently (3) mucus impacts the inflamma...
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Article
Lactate Production can Function to Increase Human Epithelial Cell Iron Concentration
Under conditions of limited iron availability, plants and microbes have evolved mechanisms to acquire iron. For example, metal deficiency stimulates reprogramming of carbon metabolism, increasing activity of e...
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Article
Open AccessInterstitial lung abnormalities and interstitial lung diseases associated with cigarette smoking in a rural cohort undergoing surgical resection
Cigarette smoking is a risk factor for interstitial lung abnormalities (ILAs) and interstitial lung diseases (ILDs). Investigation defining the relationships between ILAs/ILDs and clinical, radiographic, and p...
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Article
Correction to: Iron chelation may harm patients with COVID-19
A Correction to this paper has been published: https://doi.org/10.1007/s00228-021-03124-x
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Article
Short exposure to hyperoxia causes cultured lung epithelial cell mitochondrial dysregulation and alveolar simplification in mice
Prolonged exposure to high oxygen concentrations in premature infants, although lifesaving, can induce lung oxidative stress and increase the risk of develo** BPD, a form of chronic lung disease. The lung al...
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Article
Iron chelation may harm patients with COVID-19
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Article
Iron and zinc homeostases in female rats with physically active and sedentary lifestyles
To determine the effects of repeated physical activity on iron and zinc homeostases in a living system, we quantified blood and tissue levels of these two metals in sedentary and physically active Long-Evans r...
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Article
Letter to the editor: iron, apoptosis, and ferroptosis
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Article
Open AccessOleic acid and derivatives affect human endothelial cell mitochondrial function and vasoactive mediator production
Inhalation of common air pollutants such as diesel and biodiesel combustion products can induce vascular changes in humans which may contribute to increased mortality and morbidity associated with fine particu...
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Article
Open AccessA direct comparison of divalent metal-ion transporter (DMT1) and hinokitiol, a potential small molecule replacement
Hinokitiol, a natural lipophilic chelator, appears capable of replacing several iron transporters after they have been genetically ablated. Divalent metal-ion transporter (DMT1) is the major iron importer in e...
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Article
Human lung injury following exposure to humic substances and humic-like substances
Among the myriad particles the human respiratory tract is exposed to, a significant number are distinctive in that they include humic substances (HS) and humic-like substances (HULIS) as organic components. HS...
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Article
Open AccessA role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese
Much of iron and manganese metabolism occurs in mitochondria. Uptake of redox-active iron must be tightly controlled, but little is known about how metal ions enter mitochondria. Recently, we established that ...
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Article
Asthma as a disruption in iron homeostasis
Over several decades, asthma has evolved from being recognized as a single disease to include a diverse group of phenotypes with dissimilar natural histories, pathophysiologies, responses to treatment, and dis...
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Article
Open AccessFactors associated with self-reported health: implications for screening level community-based health and environmental studies
Advocates for environmental justice, local, state, and national public health officials, exposure scientists, need broad-based health indices to identify vulnerable communities. Longitudinal studies show that ...
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Article
Open AccessIn vitro determinants of asbestos fiber toxicity: effect on the relative toxicity of Libby amphibole in primary human airway epithelial cells
An abnormally high incidence of lung disease has been observed in the residents of Libby, Montana, which has been attributed to occupational and environmental exposure to fibrous amphiboles originating from a ...
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Oxidative Injury Caused by Cigarette Smoking and Air Pollution
Oxidative stress is pivotal to the biological effects, tissue injury, and disease following exposures to both cigarette smoke and air pollutants. Cigarette smoke and air pollutants can directly generate oxidan...
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Article
Open AccessGrowth of human bronchial epithelial cells at an air-liquid interface alters the response to particle exposure
We tested the hypothesis that normal human bronchial epithelial (NHBE) cells 1) grown submerged in media and 2) allowed to differentiate at air-liquid interface (ALI) demonstrate disparities in the response to...
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Article
Anemia and global iron fortification and supplementation
